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Multihance Side Effects

Generic Name: gadobenate dimeglumine

Note: This page contains information about the side effects of gadobenate dimeglumine. Some of the dosage forms included on this document may not apply to the brand name Multihance.

For the Consumer

Applies to gadobenate dimeglumine: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by gadobenate dimeglumine (the active ingredient contained in Multihance). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking gadobenate dimeglumine, check with your doctor or nurse immediately:

  • Abdominal or stomach pain
  • anxiety
  • back pain
  • black, tarry stools
  • bladder pain
  • bloody or cloudy urine
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chills
  • confusion
  • convulsions
  • cough
  • coughing that sometimes produces a pink frothy sputum
  • dark urine
  • decreased urination
  • deep or fast breathing with dizziness
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • difficulty with breathing or swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • excessive muscle tone
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • hives
  • inability to move the legs or arms
  • increased sweating
  • itching
  • lightheadedness, dizziness, or fainting
  • lower back or side pain
  • muscle stiffness
  • muscle tension or tightness
  • nausea
  • nervousness
  • numbness of the feet, hands, and around the mouth
  • pain in the shoulders, arms, jaw, or neck
  • pain or redness at the injection site
  • pale skin
  • pale skin at the injection site
  • paralysis of one side of the body
  • pounding heartbeat
  • pounding in the ears
  • problems with speech or speaking
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • reddening of the skin, especially around the ears
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden shortness of breath or troubled breathing
  • sugar in the urine
  • sweating
  • swelling in the legs and ankles
  • swelling of the eyes, face, or inside of the nose
  • swollen glands
  • tightness in the chest
  • tiredness
  • trembling or shaking of the hands or feet
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with gadobenate dimeglumine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • feeling hot
  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • blurred or loss of vision
  • change in sense of smell
  • change in taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased awareness or responsiveness
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • disturbed color perception
  • double vision
  • dry mouth
  • ear pain
  • feeling unusually cold
  • halos around lights
  • hearing loss
  • heartburn
  • hives or welts
  • indigestion
  • joint pain
  • lack or loss of strength
  • loss of bowel control
  • muscle aches or cramps
  • muscle spasms
  • night blindness
  • overbright appearance of lights
  • redness of the eye
  • redness of the skin
  • severe sleepiness
  • shivering
  • stomach discomfort, upset, or pain
  • stuffy nose
  • swelling of the eyelid
  • swollen joints
  • tunnel vision
  • vomiting

For Healthcare Professionals

Applies to gadobenate dimeglumine: intravenous solution


Cardiovascular side effects have included hypertension, vasodilatation, and tachycardia.[Ref]


Gastrointestinal side effects have included nausea, vomiting, and diarrhea.[Ref]


Hematologic side effects have included anemia.[Ref]

Nervous system

Nervous system side effects have included headache, paresthesia, and dizziness.[Ref]


Dermatologic side effects have included rash.[Ref]


General side effects have included taste perversion.[Ref]


Local side effects have included pain and injection site reactions.[Ref]


Hypersensitivity side effects have included anaphylactic and anaphylactoid reactions involving cardiovascular, respiratory and/or cutaneous manifestations which ranged from mild to severe. Some patients experienced circulatory collapse and died. In most cases, initial symptoms occurred within minutes of administration and resolved with prompt emergency treatment.


1. "Product Information. Multihance (gadobenate dimeglumine)." Bracco Diagnostics Inc, Princeton, NJ.

Not all side effects for Multihance may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.