Multihance Side Effects

Generic name: gadobenate dimeglumine

Medically reviewed by Drugs.com. Last updated on Dec 2, 2024.

Note: This document provides detailed information about Multihance Side Effects associated with gadobenate dimeglumine. Some dosage forms listed on this page may not apply specifically to the brand name Multihance.

Applies to gadobenate dimeglumine: intravenous solution.

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

Nephrogenic Systemic Fibrosis (NSF)Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs.

Avoid use of GBCAs in these patients unless the diagnostic information is essential and not available with non-contrasted MRI or other modalities.

NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle and internal organs.The risk for NSF appears highest among patients with chronic, severe kidney disease (GFR less than 30 mL/min/1.73 m(2)) or acute kidney injury.Screen patients for acute kidney injury and other conditions that may reduce renal function.

For patients at risk for chronically reduced renal function (eg, age greater than 60 years, hypertension or diabetes), estimate the glomerular filtration rate (GFR) through laboratory testing.For patients at highest risk for NSF, do not exceed the recommended gadobenate dimeglumine dose and allow a sufficient period of time for elimination of the drug from the body prior to re-administration

Common side effects of Multihance

Some side effects of gadobenate dimeglumine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, rash, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• feeling hot

Rare side effects

• bad, unusual, or unpleasant (after) taste
• belching
• blurred or loss of vision
• change in sense of smell
• change in taste
• continuing ringing or buzzing or other unexplained noise in the ears
• decreased awareness or responsiveness
• diarrhea
• difficulty having a bowel movement
• difficulty with moving
• disturbed color perception
• double vision
• dry mouth
• ear pain
• feeling unusually cold
• halos around lights
• hearing loss
• heartburn
• indigestion
• joint pain
• lack or loss of strength
• loss of bowel control
• muscle aches, spasms, or cramps
• night blindness
• overbright appearance of lights
• redness of the eye
• severe sleepiness
• shivering
• stomach discomfort or upset
• stuffy nose
• swollen joints
• tunnel vision
• vomiting

Serious side effects of Multihance

Along with its needed effects, gadobenate dimeglumine (the active ingredient contained in Multihance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking gadobenate dimeglumine:

Rare side effects

• anxiety
• back pain
• black, tarry stools
• bladder pain
• bloody or cloudy urine
• blue lips and fingernails
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain or discomfort
• chills
• confusion
• cough
• coughing that sometimes produces a pink frothy sputum
• dark urine
• decreased urination
• deep or fast breathing with dizziness
• difficult or labored breathing
• difficult, burning, or painful urination
• difficult, fast, or noisy breathing
• difficulty with breathing or swallowing
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• excessive muscle tone
• fainting
• fast, slow, or irregular heartbeat
• fever
• frequent urge to urinate
• general feeling of discomfort or illness
• headache
• hives, itching, skin rash
• inability to move the legs or arms
• increased sweating
• lower back or side pain
• muscle stiffness, tension, or tightness
• nausea
• nervousness
• numbness of the feet, hands, and around the mouth
• pain in the shoulders, arms, jaw, or neck
• pain or redness at the injection site
• pale skin at the injection site
• paralysis of one side of the body
• pounding heartbeat
• pounding in the ears
• problems with speech or speaking
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• reddening of the skin, especially around the ears
• seizures
• shakiness in the legs, arms, hands, or feet
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• sugar in the urine
• sweating
• swelling in the legs and ankles
• swelling of the eyes, face, or inside of the nose
• swollen glands
• tightness in the chest
• tiredness
• trembling or shaking of the hands or feet
• unusual bleeding or bruising
• unusual tiredness or weakness
• yellow eyes or skin

Incidence not known

• lack or loss of strength
• loss of consciousness
• peeling of the skin
• skin lesions

For healthcare professionals

Applies to gadobenate dimeglumine: intravenous solution.

General adverse events

General side effects have included taste perversion.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and diarrhea.^[Ref]

Hematologic

Hematologic side effects have included anemia.^[Ref]

Nervous system

Nervous system side effects have included headache, paresthesia, and dizziness.^[Ref]

Dermatologic

Dermatologic side effects have included rash.^[Ref]

Cardiovascular

Cardiovascular side effects have included hypertension, vasodilatation, and tachycardia.^[Ref]

Local

Local side effects have included pain and injection site reactions.^[Ref]

Hypersensitivity

Hypersensitivity side effects have included anaphylactic and anaphylactoid reactions involving cardiovascular, respiratory and/or cutaneous manifestations which ranged from mild to severe. Some patients experienced circulatory collapse and died. In most cases, initial symptoms occurred within minutes of administration and resolved with prompt emergency treatment.

Further information

Multihance side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer