Mechlorethamine Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 6, 2024.

Applies to mechlorethamine topical: topical application gel/jelly.

Serious side effects

Along with its needed effects, mechlorethamine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mechlorethamine topical:

More common side effects

• blistering, crusting, irritation, itching, or reddening of the skin
• cracked, dry, scaly skin
• pain, swelling, tenderness, or warmth on the skin

Other side effects

Some side effects of mechlorethamine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• darkening of the skin

For healthcare professionals

Applies to mechlorethamine topical: topical gel.

General adverse events

The most common adverse reactions (5% or greater) are dermatitis, pruritus, bacterial skin infection, skin ulceration or blistering, and hyperpigmentation^[Ref]

Hematologic

• Very common (10% or more): Reductions in hemoglobin, neutrophil count, or platelet count (13%)^[Ref]

Oncologic

• Common (1% to 10%): Nonmelanoma skin cancer^[Ref]

Ocular

• Frequency not reported: Eye pain, burns, inflammation, photophobia, blurred vision, blindness, irreversible anterior eye injury^[Ref]

Dermatologic

• Very common (10% or more): Dermatitis (56%), pruritus (20%), bacterial skin infection (11%)
• Common (1% to 10%): Skin ulceration or blistering, skin hyperpigmentation^[Ref]

Further information

Mechlorethamine topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer