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Magnevist Side Effects

Generic Name: gadopentetate dimeglumine

Medically reviewed by Last updated on July 6, 2020.

Note: This document contains side effect information about gadopentetate dimeglumine. Some of the dosage forms listed on this page may not apply to the brand name Magnevist.

For the Consumer

Applies to gadopentetate dimeglumine: intravenous solution


Intravenous route (Solution)

Gadolinium-based contrast agents (GBCAs) increase the risk for nephrogenic systemic fibrosis (NSF), in patients with impaired elimination of the drugs (ie, chronic, severe renal insufficiency (GFR less than 30 mL/min/1.73 m(2)), or acute kidney injury. Avoid use of GBCAs unless the diagnostic information is essential and not available with non-contrast enhanced MRI. NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle, and internal organs. Screen all patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (eg, age greater than 60 years, hypertension, or diabetes), perform lab testing to estimate the GFR. Do not exceed recommended dose and allow a sufficient time period for elimination prior to readministration.

Side effects requiring immediate medical attention

Along with its needed effects, gadopentetate dimeglumine (the active ingredient contained in Magnevist) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking gadopentetate dimeglumine:


  • Arm, back, or jaw pain
  • bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in skin color
  • chest pain, discomfort, tightness, or heaviness
  • chills
  • confusion
  • cough
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache, severe and throbbing
  • hives, itching, skin rash
  • irritation of the throat
  • loss of bladder control
  • loss of consciousness
  • nausea
  • nervousness
  • noisy breathing
  • pain or swelling of the treated skin
  • paleness of the skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red or irritated eyes
  • redness, tenderness, itching, burning, or peeling of the skin
  • runny nose
  • seizures
  • slow heartbeat
  • sneezing
  • sore throat
  • stuffy nose
  • sweating
  • swelling of the foot or leg
  • swelling or puffiness of the face
  • tenderness
  • total body jerking
  • unusual tiredness or weakness

Incidence not known

  • Agitation
  • blistering, peeling, or loosening of the skin
  • burning or itching of the skin
  • coughing that sometimes produces a pink frothy sputum
  • decreased urine output
  • depression
  • diarrhea
  • difficulty with speaking
  • frequent strong or increased urge to urinate
  • hoarseness
  • hostility
  • increased sweating
  • irritability
  • joint or muscle pain
  • joint stiffness
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • limited range of motion in the arms and legs
  • muscle twitching or weakness
  • no blood pressure or pulse
  • no breathing
  • pain that is deep in the hip bone or ribs
  • pain, redness, or swelling in the arm or leg
  • rapid weight gain
  • red or dark patches on the skin
  • shakiness in the legs, arms, hands, or feet
  • skin swelling, hardening, or tightening
  • slow or irregular breathing
  • sores, ulcers, or white spots in the mouth or on the lips
  • spots on your skin resembling a blister or pimple
  • stopping of the heart
  • swelling of the face, ankles, or hands
  • tenderness
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • troubled breathing

Side effects not requiring immediate medical attention

Some side effects of gadopentetate dimeglumine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


  • Bad, unusual, or unpleasant (after) taste
  • burning, dry, or itching eyes
  • change in taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decrease or change in vision
  • difficulty having a bowel movement
  • discharge or excessive tearing
  • double vision
  • dry mouth
  • ear pain
  • eye pain
  • feeling cold or warm
  • hearing loss
  • hyperventilation
  • increased salivation
  • lack or loss of strength
  • loss of appetite
  • nervousness
  • pain in the tooth
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • restlessness
  • seeing double
  • sleepiness or unusual drowsiness
  • stomach pain or discomfort
  • tearing of the eyes
  • thirst
  • trouble sleeping
  • uncontrolled eye movements
  • vomiting
  • weight loss

Incidence not known

  • Blurred or loss of vision
  • change in sense of smell
  • difficulty with moving
  • disturbed color perception
  • double vision
  • halos around lights
  • night blindness
  • overbright appearance of lights
  • poor hearing
  • tunnel vision

For Healthcare Professionals

Applies to gadopentetate dimeglumine: injectable solution


Cardiovascular side effects have included hypotension, hypertension, arrhythmia, tachycardia, syncope, vasodilation, pallor, nonspecific ECG changes, angina pectoris, death related to myocardial infarction, phlebitis, thrombophlebitis, deep venous thrombophlebitis, and compartment syndrome requiring surgery.[Ref]


Gastrointestinal side effects have included gastrointestinal distress, stomach pain, increased salivation, abdominal pain, vomiting, constipation, thirst, anorexia, dry mouth, and diarrhea.[Ref]

Nervous system

Nervous system side effects have included agitation, anxiety, migraine, nystagmus, drowsiness, stupor, paresthesia, and convulsions.[Ref]


Ocular side effects have included diplopia, conjunctivitis, visual field defect, lacrimation disorder, eye irritation, and eye pain.[Ref]


Respiratory side effects have included throat irritation, rhinorrhea, sneezing, dyspnea, wheezing, laryngismus, cough, and respiratory complaints.[Ref]


Dermatologic side effects have included rash, sweating, pruritus, urticaria, facial edema, erythema multiforme, epidural necrolysis, and pustules.[Ref]


Local side effects have included pain, localized warmth, and burning sensation at the injection site.[Ref]


Hypersensitivity side effects have included substernal chest pain, back pain, fever, weakness, generalized coldness, generalized warmth, localized edema, tiredness, chest tightness, trembling, shivering, tension in the extremities, regional lymphangitis, pelvis pain, and anaphylactoid reactions.[Ref]


Other side effects have included tinnitus and taste abnormalities.[Ref]


1. "Product Information. Magnevist (gadopentetate dimeglumine)." Berlex Laboratories, Wayne, NJ.

2. Tardy B, Guy C, Barral G, Page Y, Ollagnier M, Bertrand JC "Anaphylactic shock induced by intravenous gadopentetate dimeglumine." Lancet 339 (1992): 494

3. Garcia N, Ramon E, Gonzalez del Valle L, Ruano M, Jimenez E "Importance of a previous allergy to an iodinated contrast agent in the administration of gadopentetate dimeglumine." Ann Pharmacother 31 (1997): 374

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.