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Macugen Side Effects

Generic Name: pegaptanib ophthalmic

Note: This document contains side effect information about pegaptanib ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Macugen.

For the Consumer

Applies to pegaptanib ophthalmic: intraocular solution

Along with its needed effects, pegaptanib ophthalmic (the active ingredient contained in Macugen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pegaptanib ophthalmic:

More Common

  • Bladder pain
  • blindness
  • bloody eye
  • bloody or cloudy urine
  • blurred vision
  • burning, dry, or itching eyes
  • cough producing mucus
  • decreased vision or other changes in vision
  • difficult, burning, or painful urination
  • difficulty breathing
  • discharge, excessive tearing
  • disturbed color perception
  • double vision
  • drainage from eyes
  • eye pain
  • frequent urge to urinate
  • gradual loss of vision
  • halos around lights
  • itching of eyelid
  • looking through water
  • lower back or side pain
  • nausea
  • night blindness
  • overbright appearance of lights
  • painful irritation of the clear front part of the eye
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes
  • shortness of breath
  • sore eyes
  • swelling of the eye
  • tightness in chest
  • tunnel vision
  • vomiting
  • wheezing

Less Common

  • Bigger, dilated, or enlarged pupils (black part of the eye)
  • change in vision not present before treatment
  • chest pain
  • confusion
  • decrease in frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • dizziness or lightheadedness
  • dry mouth
  • eye irritation
  • fatigue
  • feeling of constant movement of self or surroundings
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • hearing loss
  • inability to speak
  • increased hunger
  • increased sensitivity of eyes to light
  • increased thirst
  • increased urination
  • loss of consciousness
  • numbness or tingling in face, arms, or legs
  • seeing floaters, veil or curtain appearing across part of vision
  • seizures
  • sensation of spinning
  • severe or sudden headache
  • slurred speech
  • stomachache
  • sweating
  • temporary blindness
  • trouble speaking, thinking, or walking
  • troubled breathing
  • unexplained weight loss
  • weakness in arm and/or leg on one side of the body, sudden and severe

Incidence not determined

  • Difficulty swallowing
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • unusual tiredness or weakness

Some side effects of pegaptanib ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Acid or sour stomach
  • belching
  • blistering, burning, crusting, dryness, or flaking of skin
  • bruise
  • difficulty in moving
  • heartburn
  • indigestion
  • itching, scaling, severe redness, soreness, swelling of skin
  • muscle pain or stiffness
  • pain, swelling, or redness in joints
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to pegaptanib ophthalmic: intravitreal solution

Ocular

Very common (10% to 40%): Anterior chamber inflammation, blurred vision, cataract, conjunctival hemorrhage, corneal edema, eye discharge, eye irritation, eye pain, increased intraocular pressure, ocular discomfort, punctate keratitis, reduced visual acuity, visual disturbance, vitreous floaters, vitreous opacities

Common (1% to 10%): Blepharitis, conjunctivitis, photopsia, vitreous disorder, allergic conjunctivitis, conjunctival edema, corneal abrasion, corneal deposits, corneal epithelium disorder, endophthalmitis, eye inflammation, eye swelling, eyelid irritation, meibomianitis, mydriasis, periorbital hematoma, retinal edema, vitreous hemorrhage

Uncommon (0.1% to 1%): Retinal detachment, iatrogenic traumatic cataract, other adverse events related to the injection procedure[Ref]

Cardiovascular

Very common (10% to 40%): Hypertension

Common (1% to 10%): Chest pain[Ref]

Dermatologic

Common (1% to 10%): Contact dermatitis, contusion[Ref]

Endocrine

Common (1% to 10%): Diabetes mellitus[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, dyspepsia, vomiting[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, urinary retention[Ref]

Musculoskeletal

Common (1% to 10%): Arthritis, bone spur[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, carotid artery occlusion, cerebrovascular accident, vertigo, transient ischemic attack[Ref]

Other

Common (1% to 10%): Hearing loss[Ref]

Respiratory

Common (1% to 10%): Bronchitis, pleural effusion[Ref]

Hypersensitivity

Postmarketing reports: Angioedema and other anaphylaxis/anaphylactoid[Ref]

References

1. "Product Information. Macugen (pegaptanib ophthalmic)." OSI Pharmaceuticals Inc, Melville, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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