Lymphocyte Immune Globulin, Anti-thy (equine) Side Effects

Medically reviewed by Drugs.com. Last updated on May 10, 2024.

Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection.

Important Warnings This medicine can cause some serious health issues

• Should be used only by clinicians experienced in immunosuppressive therapy for the management of renal transplant or aplastic anemia patients.^b

• Patients receiving antithymocyte globulin (equine) should be treated in facilities equipped and staffed with adequate laboratory and supportive medical resources.^b

Side effects include:

Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).

Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.

For Healthcare Professionals

Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution.

Hypersensitivity

• Uncommon (0.1% to 1%): Anaphylactic reaction^[Ref]

Dermatologic

• Very common (10% or more): Rash (26%)
• Common (1% to 10%): Urticaria, pruritus, vomiting, diarrhea, abdominal pain upper
• Uncommon (0.1% to 1%): Herpes simplex, allergic dermatitis, toxic epidermal necrolysis (TEN)
• Postmarketing reports: Hyperhidrosis^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (17%)
• Common (1% to 10%): Chest pain, back pain^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea
• Uncommon (0.1% to 1%): Stomatitis
• Postmarketing reports: Abdominal pain, GI hemorrhage, GI perforation, oral pain^[Ref]

Cardiovascular

• Common (1% to 10%): Thrombophlebitis, hypertension, hypotension, bradycardia, arteriovenous fistula thrombosis, tachycardia, iliac vein occlusion
• Postmarketing reports: Congestive heart failure, deep vein thrombosis, vasculitis^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (22%), leukopenia (18%)
• Postmarketing reports: Anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, neutropenia, pancytopenia^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea
• Uncommon (0.1% to 1%): Pleural effusion, hiccups, laryngospasm, pulmonary edema
• Postmarketing reports: Apnea, cough, epistaxis, oropharyngeal pain^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Uncommon (0.1% to 1%): Convulsion, encephalitis, paresthesia
• Postmarketing reports: Dyskinesia, Syncope, tremor^[Ref]

Local

• Common (1% to 10%): Infusion site pain
• Postmarketing reports: Infusion site erythema, infusion site swelling^[Ref]

Renal

• Uncommon (0.1% to 1%): Renal function test abnormal, renal artery thrombosis
• Postmarketing reports: Kidney rupture, renal failure acute^[Ref]

Ocular

• Uncommon (0.1% to 1%): Periorbital edema^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Night sweats, hyperglycemia, proteinuria
• Postmarketing reports: Flank pain, muscle rigidity, myalgia, pain in extremity^[Ref]

Hepatic

• Common (1% to 10%): Liver function test abnormal^[Ref]

Immunologic

• Common (1% to 10%): Infection
• Uncommon (0.1% to 1%): Serum sickness
• Postmarketing reports: Hepatitis viral, localized infection, systemic infection^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Agitation
• Postmarketing reports: Confusion, disorientation^[Ref]

Other

• Very common (10% or more): Pyrexia (40%), chills (27%)
• Common (1% to 10%): Edema, lymphadenopathy, asthenia, malaise, wound dehiscence
• Postmarketing reports: Aplasia, pain^[Ref]

Further information

Lymphocyte immune globulin, anti-thy (equine) side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer