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Lymphocyte Immune Globulin, Anti-Thy (Equine) Dosage

Applies to the following strength(s): 50 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Aplastic Anemia

10 to 20 mg/kg/day by IV infusion for 8 to 14 days. Additional alternating day therapy can be administered for up to a total of 21 doses.

Usual Adult Dose for Renal Transplant

Delaying the Onset of Allograft Rejection:
15 mg/kg daily for 14 days, then every other day for 14 days for a total of 21 doses in 28 days. Administer the first dose within 24 hours before or after the transplant.

Rejection treatment:
10 to 15 mg/kg/day by IV infusion for 14 days. Additional alternating day therapy can be administered for up to 21 doses.

Usual Pediatric Dose for Aplastic Anemia

Experience with children has been limited. Lymphocyte immune globulin has been administered safely to a small number of pediatric renal allograft recipients and pediatric aplastic anemia patients at dosage levels comparable to those in adults.

10 to 20 mg/kg/day for 8 to 14 days. Additional alternating day therapy can be administered for up to 21 doses in 28 days.

Usual Pediatric Dose for Renal Transplant

Experience with children has been limited. Lymphocyte immune globulin has been administered safely to a small number of pediatric renal allograft recipients and pediatric aplastic anemia patients at dosage levels comparable to those in adults.

Induction therapy:
15 mg/kg/day by IV infusion for 14 days, followed by 15 mg/kg every other day for 14 days for a total of 21 doses in 28 days. Administer the first dose within 24 hours before or after the transplant.

Delaying the Onset of Allograft Rejection:
15 mg/kg daily for 14 days, then every other day for 14 days for a total of 21 doses in 28 days. Administer the Induction therapy: first dose within 24 hours before or after the transplant.

Rejection treatment:
10 to 15 mg/kg/day by IV infusion for 14 days. Additional alternating day therapy can be administered for up to 21 doses.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Data not available

Precautions

Serious and occasionally fatal hypersensitivity reactions have been reported. Lymphocyte immune globulin should be discontinued immediately at the first appearance of a skin rash or other signs of hypersensitivity. Severe, acute hypersensitivity reactions may require treatment with epinephrine and other resuscitative measures including oxygen, intravenous fluids, antihistamines, corticosteroids, cardiovascular support and airway management as clinically indicated.

Skin testing with a 1:1,000 dilution is strongly recommended before administration.

Dialysis

Data not available

Other Comments

Lymphocyte immune globulin should only be administered into a vascular shunt, arterial venous fistula, or high flow central vein through an inline filter with a pore size of 0.2 to 1.0 micron. The use of a high flow filter will minimize the occurrence of phlebitis and thrombosis.

Lymphocyte immune globulin should be infused over at least 4 hours.

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