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Lipsovir Side Effects

Generic Name: acyclovir / hydrocortisone topical

Note: This page contains information about the side effects of acyclovir / hydrocortisone topical. Some of the dosage forms included on this document may not apply to the brand name Lipsovir.

For the Consumer

Applies to acyclovir / hydrocortisone topical: topical application cream

In addition to its needed effects, some unwanted effects may be caused by acyclovir / hydrocortisone topical. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking acyclovir / hydrocortisone topical:

  • Burning, itching, redness, rash, swelling, soreness, or tingling at the application site
  • change in skin color at the application site
  • dryness or flaking of the skin
  • flushing or redness of the skin
  • unusually warm skin
Incidence not known:
  • Blistering, burning, or crusting of the skin
  • itching, scaling, severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to acyclovir / hydrocortisone topical: topical cream


During clinical trials, most side effects were local skin reactions and occurred around the application site.[Ref]


Uncommon (0.1% to 1%): Local skin reactions in application site area (including drying or flaking of skin, burning or tingling after application, erythema, pigmentation changes, application site reaction [including signs/symptoms of inflammation])
Frequency not reported: High and cumulative irritation potential[Ref]

A high and cumulative irritation potential under occlusive and semiocclusive conditions was reported during a 21-day cumulative irritation trial.[Ref]


Frequency not reported: Contact allergy, sensitization to hydrocortisone, possible sensitization to drug's base[Ref]

During a photosafety study, one subject developed a contact allergy to propylene glycol (one of the inactive ingredients of the cream base).[Ref]


Frequency not reported: Contact dermatitis[Ref]


1. "Product Information. Xerese (acyclovir-hydrocortisone topical)." Meda Pharmaceuticals, Somerset, NJ.

Not all side effects for Lipsovir may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Lipsovir (acyclovir / hydrocortisone topical)

Consumer resources

Other brands: Xerese

Professional resources

Related treatment guides

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