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KG-Tussin Side Effects

Generic Name: chlorpheniramine / hydrocodone / pseudoephedrine

Note: This document contains side effect information about chlorpheniramine / hydrocodone / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name KG-Tussin.

For the Consumer

Applies to chlorpheniramine/hydrocodone/pseudoephedrine: oral solution

Along with its needed effects, chlorpheniramine/hydrocodone/pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlorpheniramine / hydrocodone / pseudoephedrine:

More Common

  • Fainting
  • lightheadedness
  • shakiness in the legs, arms, hands, or feet
  • trembling or shaking of the hands or feet
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Incidence Not Known

  • Bloating
  • blurred vision
  • bulging soft spot on the head of an infant
  • change in the ability to see colors, especially blue or yellow
  • confusion
  • constipation
  • decrease in the frequency of urination
  • decrease in the urine volume
  • diarrhea
  • difficult or troubled breathing
  • difficulty in passing urine (dribbling)
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • fast, slow, or irregular heartbeat
  • headache
  • hives or welts, itching, skin rash
  • irregular, fast or slow, or shallow breathing
  • loss of appetite
  • loss of consciousness
  • nervousness
  • painful urination
  • pale or blue lips, fingernails, or skin
  • pounding in the ears
  • seizures
  • sore throat
  • spasm of the throat
  • stomach cramps or pain
  • sweating
  • tightness of the chest
  • vomiting
  • yellow eyes or skin

Some side effects of chlorpheniramine / hydrocodone / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Deep or fast breathing with dizziness
  • disturbed color perception
  • double vision
  • dry mouth
  • false or unusual sense of well-being
  • fear or nervousness
  • halos around lights
  • nausea
  • night blindness
  • numbness of the feet, hands, and around the mouth
  • overbright appearance of lights
  • relaxed and calm feeling
  • restlessness
  • sleepiness or unusual drowsiness
  • trouble sleeping
  • tunnel vision

Incidence Not Known

  • Belching
  • bigger, dilated, or enlarged pupils (black part of the eye)
  • bloating
  • change in color vision
  • chills
  • cold sweats
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cool, pale skin
  • darkened urine
  • depression
  • difficulty seeing at night
  • feeling of constant movement of self or surroundings
  • fever
  • flushing or redness of the skin
  • full feeling
  • hearing loss
  • heartburn
  • increased appetite
  • increased hunger
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • increased sensitivity of the eyes to sunlight
  • increased sweating
  • indigestion
  • nightmares
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pressure in the stomach
  • sensation of spinning
  • slurred speech
  • stomach discomfort or upset
  • sugar in the urine
  • swelling of the abdominal or stomach area
  • swelling of the breasts or breast soreness in both females and males
  • unusually warm skin
  • watering of the eyes

For Healthcare Professionals

Applies to chlorpheniramine / hydrocodone / pseudoephedrine: oral capsule, oral liquid, oral suspension extended release, oral syrup, oral tablet


The more commonly reported adverse effects have included sedation (somnolence, mental clouding, lethargy), lightheadedness, headache, dry mouth, restlessness, nausea, vomiting, constipation, tachycardia, arrhythmias including premature ventricular contractions, CNS stimulation including anxiety, restlessness, nervousness, tremor, and irritability.[Ref]


Frequency not reported: Bronchitis, cough, dyspnea, nasal congestion, nasopharyngitis, respiratory depression including fatal respiratory depression, sinusitis, upper respiratory tract infection, thickening of bronchial secretions, tightness of chest wheezing, dry nose, dry throat


Frequency not reported: Abdominal pain, acute pancreatitis, bowel obstruction, diarrhea, difficulty swallowing, GERD, indigestion, pancreatitis, paralytic ileus, dysgeusia, ischemic colitis, increase of serum amylase, dry mouth, biliary tract spasm (spasm of the sphincter of Oddi)

Nervous system

Frequency not reported: Coma, somnolence, facial dyskinesia, tremor, insomnia, migraine, increased intracranial pressure, seizure, dizziness, decreased mental alertness with impaired mental and/or physical abilities, serotonin syndrome, tinnitus

Serotonin syndrome has been reported with concomitant opioids and serotonergic drugs


Frequency not reported: Confusion, anxiety, dysphoria, agitation, addiction, abuse, misuse, fear, depression, hyperactivity, ataxia, hallucinations, hyperexcitability, opioid withdrawal syndrome


Frequency not reported: Ureteral spasm, spasm of vesicle sphincters, urinary retention, urinary tract infection, hypogonadism, infertility


Frequency not reported: Increased blood pressure, decreased blood pressure, tachycardia, chest pain, orthostatic hypotension, palpitations, syncope, prolonged QT interval, hot flush, atrial fibrillation, myocardial infarction, arrhythmias including premature ventricular contractions, flushing


Frequency not reported: Vertigo, peripheral edema, death, falling injuries, weakness, hyperthermia, ataxia, accidental overdose, neonatal opioid withdrawal syndrome


Frequency not reported: Anaphylaxis


Frequency not reported: Hyperhidrosis, rash, pruritus, erythema, severe reactions such as acute generalized exanthematous pustulosis (AGEP)


Frequency not reported: Adrenal insufficiency, androgen deficiency

Adrenal insufficiency has been reported with opioid use, most often following greater than one month of use. Androgen deficiency has been reported with chronic opioid use.


Frequency not reported: Blurred vision, mydriasis, miosis, visual disturbances, diplopia


Frequency not reported: Decreased appetite


Frequency not reported: Agranulocytosis, aplastic anemia, thrombocytopenia


Frequency not reported: Arthralgia, backache, muscle spasm


1. "Product Information. Zutripro (chlorpheniramine/hydrocodone/PSE)." Hawthorn Pharmaceuticals, Madison, MS.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about KG-Tussin (chlorpheniramine / hydrocodone / pseudoephedrine)

Consumer resources

Other brands: Hydron PCS, Hyphed, Notuss-Forte, Zutripro

Professional resources

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