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Chlorpheniramine / Hydrocodone / Pseudoephedrine Dosage

Medically reviewed on January 22, 2018.

Applies to the following strengths: 2 mg-2.5 mg-30 mg/5 mL; 2 mg-3 mg-15 mg/5 mL; 2 mg-2.5 mg-15 mg/5 mL; 4 mg-5 mg-60 mg/5 mL; 2 mg-5 mg-30 mg/5 mL; 4 mg-5 mg-40 mg/5 mL; 4 mg-5 mg-30 mg/5 mL; 2 mg-5 mg-30 mg; 2.5 mg-1.67 mg-20 mg/5 mL; 2.5 mg-1.67 mg-17.5 mg/5 mL; 4 mg-5 mg-60 mg

Usual Adult Dose for Cough and Nasal Congestion

Chlorpheniramine/hydrocodone/pseudoephedrine 4 mg-5 mg-60 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours
Maximum dose: Not to exceed 4 doses per day

-Measure dose with accurate measuring device.

Use: Symptomatic relief of cough and nasal congestion associated with the common cold and symptomatic relief of nasal congestion associated with upper respiratory allergies.

Renal Dose Adjustments

Severe renal impairment: Use with caution

Liver Dose Adjustments

Severe hepatic impairment: Use with caution

Dose Adjustments

Elderly: Use with caution


-Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol.

Safety and efficacy of the immediate-release oral solution have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II


Data not available

Other Comments

Administration advice:
-Measure oral solution with an accurate measuring device; a household teaspoon is not an accurate measuring device

Storage: Protect from light

-This product is not indicated in children as safety and effectiveness has not been demonstrated; leading pediatric and pulmonary health organizations recommend against symptomatic treatment of cough in pediatric patients due to lack of efficacy studies and the possibility of significant morbidity and mortality.

-Monitor for the development of addiction, abuse, or misuse

Patient advice:
-Advise patients to store this drug safely out of the sight and reach of children; accidental use by a child is a medical emergency and can result in death.
-Patients should understand the risks of life-threatening respiratory depression, and should be informed as to when this risk is greatest.
-Patients should discuss concomitant medication use with their healthcare provider to prevent significant drug interactions.
-Women of child bearing potential should understand that prolonged opioid use during pregnancy can result in neonatal opioid withdrawal syndrome and that prompt recognition and treatment will be necessary; breastfeeding women should speak to their health care provider prior to using this drug.
-Patients should not consume alcoholic beverages or take this drug with benzodiazepines or other CNS depressants; patients should avoid driving or operating machinery while taking this drug.
-Patients should be instructed in proper disposal.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.