Journavx Side Effects
Generic name: suzetrigine
Note: This document provides detailed information about Journavx Side Effects associated with suzetrigine. Some dosage forms listed on this page may not apply specifically to the brand name Journavx.
Applies to suzetrigine: oral tablet.
Important warnings
This medicine can cause some serious health issues
Tell your doctor about all your other medicines.
Some drugs should not be used with suzetrigine.
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Less serious side effects may be more likely, or you may have none at all.
Common side effects may include:
-
skin rash;
-
muscle spasm; or
-
abnormal lab tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For healthcare professionals
Applies to suzetrigine: oral tablet.
General adverse events
The most common adverse reactions were increased creatine phosphokinase, muscle spasms, pruritus, and rash.[Ref]
Cardiovascular
- Uncommon (0.1% to 1%): Arrhythmia, hypotension, tachycardia[Ref]
Dermatologic
- Common (1% to 10%): Pruritus, rash[Ref]
Gastrointestinal
Hematologic
- Uncommon (0.1% to 1%): Postprocedural hematoma[Ref]
Musculoskeletal
- Common (1% to 10%): Muscle spasms[Ref]
Nervous system
Other
- Common (1% to 10%): Creatine phosphokinase (CPK) elevations[Ref]
In Trials 1 and 2, 2.9% of patients had a CPK level greater than 3 times the upper limit of normal. All reports of CPK elevations occurred in the post-surgical setting.[Ref]
Renal
- Common (1% to 10%): Decreased estimated glomerular filtration (eGFR) rate[Ref]
In Trials 1 and 2, 2.5% of patients had a decrease in eGFR of 25% to less than 50%.[Ref]
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References
1. (2025) "Product Information. Journavx (suzetrigine)." Vertex Pharmaceuticals
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Further information
Journavx side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.