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Ioxilan Side Effects

Applies to ioxilan: injectable solution

General

General side effects including headache (3.6%), fever (1.7%), chills (0.6%), asthenia, chest and back pain, edema of the neck, facial edema, pain, and peripheral edema have been reported.[Ref]

Cardiovascular

Common (1% to 10%): Angina pectoris (1.3%), hypertension (1.1%)
Uncommon (0.1% to 1%): Bradycardia, hypotension, atrial fibrillation, syncope, tachycardia, vasodilation, ventricular extrasystole[Ref]

Severe life-threatening cardiovascular reactions and fatalities have occurred. Most deaths occur during injection or 5 to 10 minutes later; the main feature being cardiac arrest with cardiovascular disease as the main aggravating factor.[Ref]

Gastrointestinal

Common (1% to 10%): Nausea (1.5%)
Uncommon (0.1% to 1%): Diarrhea, nausea with vomiting, constipation, dyspepsia, dysphagia, gastrointestinal hemorrhage, ileus[Ref]

Nervous system

Common (1% to 10%): Headache (3.6%)
Uncommon (0.1% to 1%): Dizziness, hypotonia, nystagmus, paresthesia, somnolence, vertigo, taste perversion[Ref]

Other

Common (1% to 10%): Fever (1.7%)
Uncommon (0.1% to 1%): Chills, asthenia, edema of the neck, facial edema, pain, peripheral edema[Ref]

Dermatologic

Uncommon (0.1% to 1%): Urticaria, rash, pruritus, sweating[Ref]

Endocrine

Uncommon (0.1% to 1%): Hypothyroidism or transient thyroid suppression[Ref]

Genitourinary

Uncommon (0.1% to 1%): Anuria, dysuria, hematuria, urinary tract infection, urination impairment[Ref]

Hepatic

Uncommon (0.1% to 1%): Liver failure[Ref]

Hypersensitivity

The reported incidence of adverse reactions to contrast agents in patients with a history of allergy is twice that of the general population. Patients with a history of previous reactions to a contrast agent are three times more susceptible than other patients. However, sensitivity to contrast agents does not appear to increase with repeated examinations.[Ref]

Uncommon (0.1% to 1%): Allergic reaction[Ref]

Local

Uncommon (0.1% to 1%): Hematoma at the injection site[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Chest and back pain[Ref]

Ocular

Uncommon (0.1% to 1%): Amblyopia, conjunctivitis, vision abnormality[Ref]

Renal

Uncommon (0.1% to 1%): Kidney failure[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea, pharyngitis, rhinitis
Postmarketing reports: Bronchospasm[Ref]

References

1. "Product Information. Oxilan (ioxilan)." Guerbet LLC, Bloomington, IN.

Not all side effects for ioxilan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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