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Ioxilan Side Effects

Applies to ioxilan: injectable solution

General

General side effects including headache (3.6%), fever (1.7%), chills (0.6%), asthenia, chest and back pain, edema of the neck, facial edema, pain, and peripheral edema have been reported.[Ref]

Cardiovascular

Common (1% to 10%): Angina pectoris (1.3%), hypertension (1.1%)
Uncommon (0.1% to 1%): Bradycardia, hypotension, atrial fibrillation, syncope, tachycardia, vasodilation, ventricular extrasystole[Ref]

Severe life-threatening cardiovascular reactions and fatalities have occurred. Most deaths occur during injection or 5 to 10 minutes later; the main feature being cardiac arrest with cardiovascular disease as the main aggravating factor.[Ref]

Gastrointestinal

Common (1% to 10%): Nausea (1.5%)
Uncommon (0.1% to 1%): Diarrhea, nausea with vomiting, constipation, dyspepsia, dysphagia, gastrointestinal hemorrhage, ileus[Ref]

Nervous system

Common (1% to 10%): Headache (3.6%)
Uncommon (0.1% to 1%): Dizziness, hypotonia, nystagmus, paresthesia, somnolence, vertigo, taste perversion[Ref]

Other

Common (1% to 10%): Fever (1.7%)
Uncommon (0.1% to 1%): Chills, asthenia, edema of the neck, facial edema, pain, peripheral edema[Ref]

Dermatologic

Uncommon (0.1% to 1%): Urticaria, rash, pruritus, sweating[Ref]

Endocrine

Uncommon (0.1% to 1%): Hypothyroidism or transient thyroid suppression[Ref]

Genitourinary

Uncommon (0.1% to 1%): Anuria, dysuria, hematuria, urinary tract infection, urination impairment[Ref]

Hepatic

Uncommon (0.1% to 1%): Liver failure[Ref]

Hypersensitivity

The reported incidence of adverse reactions to contrast agents in patients with a history of allergy is twice that of the general population. Patients with a history of previous reactions to a contrast agent are three times more susceptible than other patients. However, sensitivity to contrast agents does not appear to increase with repeated examinations.[Ref]

Uncommon (0.1% to 1%): Allergic reaction[Ref]

Local

Uncommon (0.1% to 1%): Hematoma at the injection site[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Chest and back pain[Ref]

Ocular

Uncommon (0.1% to 1%): Amblyopia, conjunctivitis, vision abnormality[Ref]

Renal

Uncommon (0.1% to 1%): Kidney failure[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea, pharyngitis, rhinitis
Postmarketing reports: Bronchospasm[Ref]

References

1. "Product Information. Oxilan (ioxilan)." Guerbet LLC, Bloomington, IN.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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