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Omnipaque 240

Generic Name: iohexol (Injection route, Oral route, Rectal route)

eye-oh-HEX-ol

Commonly used brand name(s)

In the U.S.

  • Omnipaque 140
  • Omnipaque 180
  • Omnipaque 240
  • Omnipaque 300
  • Omnipaque 350
  • Omnipaque Flexipak

Available Dosage Forms:

  • Solution

Therapeutic Class: Radiological Non-Ionic Contrast Media

Uses For Omnipaque 240

Iohexol injection is used to help diagnose or find problems in the brain, back, heart, head, blood vessels, and other parts of the body. It is an iodinated contrast agent. Contrast agents are used to create a clear picture of the different parts of the body during certain medical procedures such as CT scans and angiography.

Iohexol may also be given orally or rectally to help diagnose or find problems in the joints, stomach or intestines, pancreas, and other parts of the body.

This medicine is to be given only by or under the supervision of a doctor.

Before Using Omnipaque 240

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of iohexol in children. Some pediatric patients with certain medical conditions may have more unwanted side effects which may require caution in patients receiving iohexol.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of iohexol in the elderly. However, elderly patients are more likely to have unwanted side effects which may require caution in patients receiving iohexol.

Pregnancy

Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Metformin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Heart or blood vessel disease or
  • Multiple sclerosis or
  • Seizures or epilepsy, history of—Iohexol injection should be used with caution in these patients.
  • Allergies or hypersensitivities, or
  • Allergic rhinitis (hay fever) or
  • Allergy to a contrast agent, history of or
  • Allergy to food or
  • Allergy to iodine or
  • Asthma—Use with caution. May increase risk of having allergic reactions.
  • Anuria (not able to pass urine) or
  • Blood vessel disease, severe or
  • Congestive heart failure or
  • Dehydration or
  • Diabetes or
  • Diabetic nephropathy or
  • Kidney disease or
  • Multiple myeloma (cancer of plasma cells) or
  • Paraproteinemia (high amount of paraprotein in the blood)—May increase risk of having kidney failure.
  • Blood clotting problems (eg, thrombosis) or
  • Heart or blood vessel disease (eg, arteriosclerosis) or
  • Hypertension (high blood pressure) or
  • Hyperthyroidism (overactive thyroid) or
  • Kidney disease, severe or
  • Liver disease or
  • Pheochromocytoma (adrenal problem) or
  • Sickle cell anemia (inherited blood disorder)—Use with caution. May make these conditions worse.
  • Homocystinuria (genetic disease)—Patients with this condition should avoid undergoing angiography because of the increased risk of having blood clotting problems.
  • Infection—Iohexol injection should not be given for myelography in patients with this condition.

Proper Use of iohexol

This section provides information on the proper use of a number of products that contain iohexol. It may not be specific to Omnipaque 240. Please read with care.

A doctor or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in an artery or a vein, or into your spinal cord. It may also be given by mouth or through your rectum.

Your doctor may also give you medicines (eg, antihistamines, steroids) to prevent allergic reactions.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems.

Precautions While Using Omnipaque 240

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Tell your doctor if you are pregnant.

This medicine may cause heart attack, stroke, and blood clotting problems during angiographic procedures. Tell your doctor right away if you have chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness, coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, or problems with vision, speech, or walking after receiving this medicine.

Severe kidney problems may occur after receiving this medicine. Tell your doctor right away if you have the following symptoms after receiving the medicine: agitation, confusion, decreased urine output, dizziness, headache, muscle twitching, rapid weight gain, or swelling of the face, ankles, or hands.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a skin rash, itching, shortness of breath, sweating, swelling of the face, tongue, and throat, or tightness in the chest after you receive this medicine.

Make sure your doctor knows if you have had an allergic reaction to any dye or medicine given during a test or procedure.

While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.

Make sure any doctor or dentist who treats you knows that you are using iohexol injection. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. You should not receive iohexol injection together with a steroid medicine into your spinal cord.

Omnipaque 240 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common—Oral or rectal route
  • Swelling or pain
Less common—Intravascular route
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • difficulty breathing
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • nausea
  • shortness of breath
  • sweating
  • swelling in the throat
Less common—Oral or rectal route
  • Blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness
Rare—Intrathecal route
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • feeling of constant movement of self or surroundings
  • headache
  • nervousness
  • pounding in the ears
  • seizures
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness
Rare—Intravascular route
  • Blurred vision
  • confusion
  • dilated neck veins
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fast, pounding, or irregular heartbeat or pulse
  • feeling cold
  • feeling of constant movement of self or surroundings
  • fever
  • irregular breathing
  • pale skin
  • seizures
  • sensation of spinning
  • swelling of the face, fingers, feet, or lower legs
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weight gain
Rare—Oral or rectal route
  • Muscle weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common—Intrathecal route
  • Nausea
  • pain in the neck, back, or nerve
More common—Oral or rectal route
  • Abdominal or stomach pain
  • bloated or full feeling
  • diarrhea
  • excess air or gas in the stomach or intestines
  • nausea
  • passing gas
  • vomiting
Less common—Intrathecal route
  • Vomiting
Less common—Intravascular route
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • headache
Less common—Oral or rectal route
  • Hives or welts, itching, or skin rash
  • redness of the skin
  • sleepiness or unusual drowsiness
Rare—Intrathecal route
  • Change in color vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty seeing at night
  • drowsiness
  • hearing loss
  • increased sensitivity of the eyes to sunlight
  • loss of appetite
  • sensation of spinning
Rare—Intravascular route
  • Acid or sour stomach
  • anxiety
  • belching
  • chills
  • cold sweats
  • coma
  • cool, pale skin
  • cough
  • depression
  • diarrhea
  • dry mouth
  • heartburn
  • hives or welts, itching, or rash
  • increased hunger
  • indigestion
  • nightmares
  • redness of the skin
  • runny nose
  • shakiness
  • sleepiness or unusual drowsiness
  • slurred speech
  • sneezing
  • stomach discomfort, upset, or pain
  • stuffy nose
  • uncontrolled eye movements
  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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