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Ioxilan Dosage

Applies to the following strengths: 300 mg/mL; 350 mg/mL

Usual Adult Dose for Cerebral Arteriography

Use ioxilan injection 300 mgI/mL:
2.4 to 3.6 gI (8 mL to 12 mL) by intraarterial injection
Maximum dose: Total of 150 mL per procedure

Comment: Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).

Use: Radiographic contrast evaluation of arterial lesions of the brain

Usual Adult Dose for Coronary Arteriography

Use ioxilan injection 350 mgI/mL:
-Left and Right Coronary: 0.7 to 3.5 gI (2 mL to 10 mL) by intraarterial injection
-Left Ventricle: 8.75 to 17.5 gI (25 mL to 50 mL) by intraarterial injection
Maximum dose: Total of 250 mL per procedure

Comments:
-Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).
-Injection rates should be approximately equal to flow rate in the vessel being injected.
-Allow sufficient time to elapse between each injection to avoid possible hemodynamic disturbances when large individual volumes are administered, as in ventriculography and aortography.

Use: Radiographic contrast evaluation of coronary arteries and the left ventricle

Usual Adult Dose for Left Ventriculography

Use ioxilan injection 350 mgI/mL:
-Left and Right Coronary: 0.7 to 3.5 gI (2 mL to 10 mL) by intraarterial injection
-Left Ventricle: 8.75 to 17.5 gI (25 mL to 50 mL) by intraarterial injection
Maximum dose: Total of 250 mL per procedure

Comments:
-Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).
-Injection rates should be approximately equal to flow rate in the vessel being injected.
-Allow sufficient time to elapse between each injection to avoid possible hemodynamic disturbances when large individual volumes are administered, as in ventriculography and aortography.

Use: Radiographic contrast evaluation of coronary arteries and the left ventricle

Usual Adult Dose for Peripheral Arteriography

Use ioxilan injection 350 mgI/mL:
-Aortic bifurcation for distal runoff: 26 to 70 gI (45 mL to 100 mL) by intraarterial injection
-Subclavian or femoral artery: 4 to 14 gI (10 mL to 40 mL) by intraarterial injection
Maximum dose: Total of 250 mL per procedure

Comments:
-Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).
-Pulsation should be present in the artery to be injected.
-Injection rates should be approximately equal to flow rate in the vessel being injected.

Use: Radiographic contrast evaluation of peripheral arteries

Usual Adult Dose for Visceral Arteriography

Use ioxilan injection 350 mgI/mL:
-The volume and rate of contrast injection should be proportional to the blood flow through the vessels of interest, and related to the vascular and pathological characteristics of the specific vessels being studied.
-Maximum dose: Total of 250 mL per procedure

Comment: Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).

Use: Radiographic contrast evaluation of the aorta and major visceral arterial branches

Usual Adult Dose for Aortography

Use ioxilan injection 350 mgI/mL:
-The volume and rate of contrast injection should be proportional to the blood flow through the vessels of interest, and related to the vascular and pathological characteristics of the specific vessels being studied.
-Maximum dose: Total of 250 mL per procedure

Comment: Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).

Use: Radiographic contrast evaluation of the aorta and major visceral arterial branches

Usual Adult Dose for Intravenous Urography

Use ioxilan injection 300 mgI/mL or 350 mgI/mL:
250 to 390 mgI/kg of body weight as intravenous injection
Maximum dose: Total of 100 mL per procedure

Comment: Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).

Use: Routine excretory urography

Usual Adult Dose for Head Imaging

Contrast Enhanced Computed Tomography (CECT):
-CECT of the Head: 30 to 60 gI by intravenous injection. Scanning may be performed immediately after completion of the intravenous administration.
-CECT of the Body: 15 to 60 gI intravenously by bolus, by rapid infusion, or by a combination of both
Maximum dose: Total of 200 mL per procedure

Comment:
-Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).
-Use ioxilan injection 300 mgI/mL or 350 mgI/mL.

Use: Contrast enhancement in the evaluation of neoplastic and non- neoplastic lesions of the head and body (intrathoracic, intraabdominal, and retroperitoneal regions)

Usual Adult Dose for Body Imaging

Contrast Enhanced Computed Tomography (CECT):
-CECT of the Head: 30 to 60 gI by intravenous injection. Scanning may be performed immediately after completion of the intravenous administration.
-CECT of the Body: 15 to 60 gI intravenously by bolus, by rapid infusion, or by a combination of both
Maximum dose: Total of 200 mL per procedure

Comment:
-Doses are expressed as gram-Iodine (gI) or milligram-Iodine (mgI).
-Use ioxilan injection 300 mgI/mL or 350 mgI/mL.

Use: Contrast enhancement in the evaluation of neoplastic and non- neoplastic lesions of the head and body (intrathoracic, intraabdominal, and retroperitoneal regions)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNING(S):
-Not for intrathecal use.
-Pharmacy bulk package is not for direct infusion.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Only for intravenous and intraarterial use.
-Mandatory prerequisites to the procedure are specialized personnel, ECG monitoring apparatus and adequate facilities for immediate resuscitation and cardioversion.
-The maximum recommended total dose of iodine is 86 grams.
-Intravascularly administered iodinated contrast agents should be at or close to body temperature when injected.
-The injection should be immediately stopped if reaction occurs.
-Adequately hydration prior to and following intravascular administration is recommended.
-The combination of volume and concentration to be used should be carefully individualized based on age, body weight, size of the vessel and the rate of blood flow within the vessel.
-Lower doses may have less risk. The efficacy of doses below the recommended has not been studied.
-Consider other factors such as anticipated pathology, degree and extent of opacification required, structures or area to be examined, disease processes affecting the patient, and equipment and technique to be employed.

Storage requirements:
-Store at room temperature between 15C and 30C (59F and 86F) and protect from light.
-Do not freeze.

Preparation techniques:
-Preparation of the injection is restricted to a suitable work area, such as a laminar flow hood.
-The manufacturer product information should be consulted.

General:
-The decision to use contrast enhancement is associated with risk and increased radiation exposure, and should be based upon a careful evaluation of clinical, other radiologic data, and of unenhanced CT findings.
-Diagnostic procedures with this drug should be carried out under the direction of personnel skilled and experienced in the procedure.

Monitoring:
-Electrocardiograms and vital signs should be routinely monitored throughout the procedure.

Patient advice:
-Inform your physician if you are diabetic, have multiple myeloma, pheochromocytoma, homozygous sickle cell disease, or known thyroid disorder.
-Inform your physician if you are allergic to any drugs, food, or if you have immune, autoimmune or immune deficiency disorders. Also inform your physician if you had any reactions to previous injections of dyes used for x- ray procedures.
-Inform your physician about all medications you are currently taking, including non-prescription drugs, before the procedure.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.