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Ingenol topical Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 23, 2022.

In Summary

Commonly reported side effects of ingenol topical include: dermal ulcer, localized vesiculation, skin erosion, swelling of skin, and erythema of skin. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ingenol topical: topical gel

Side effects include:

Local skin reactions: Erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation, erosion/ulceration.

Application site reactions: Pain, pruritus.

For Healthcare Professionals

Applies to ingenol topical: topical gel

General

The most commonly reported side effects were local skin responses including erythema, flaking/scaling, crusting, swelling, vesiculation/postulation, and erosion.[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions[Ref]

Local

Very common (10% or more): Application site erythema (up to 94%), application site exfoliation (up to 90%), application site scab (up to 80%), application site swelling (up to 79%), application site erosion/ulceration (up to 32%), application site vesicles (up to 20%), application site pain (including application site burning) (up to 15%)

Common (1% to 10%): Application site pruritus, application site irritation

Uncommon (0.1% to 1%): Application site discharge, application site paresthesia, application site ulcer, application site warmth[Ref]

Dermatologic

Very common (10% or more): Flaking/scaling (85%), crusting (80%), vesiculation/postulation (56%)

Postmarketing reports: Allergic contact dermatitis, application site pigmentation changes, application site scarring, chemical conjunctivitis[Ref]

Immunologic

Very common (10% or more): Application site pustules (up to 43%)

Common (1% to 10%): Application site infection

Postmarketing reports: Herpes zoster[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Ocular

Common (1% to 10%): Eye lid edema, periorbital edema

Uncommon (0.1% to 1%): Eyelid pain

Frequency not reported: Chemical conjunctivitis, corneal burn, eyelid ptosis[Ref]

Other

Very common (10% or more): Swelling (79%)[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Picato (ingenol topical)." Leo Pharma Inc, Parsippany, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.