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Idhifa Side Effects

Generic Name: enasidenib

Note: This document contains side effect information about enasidenib. Some of the dosage forms listed on this page may not apply to the brand name Idhifa.

For the Consumer

Applies to enasidenib: oral tablet

Along with its needed effects, enasidenib (the active ingredient contained in Idhifa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enasidenib:

More common
  • Agitation
  • blue lips, fingernails, or skin
  • bone pain
  • chest pain
  • chills
  • confusion
  • cough
  • coughing that sometimes produces a pink frothy sputum
  • decreased awareness or responsiveness
  • decreased urine output
  • depression
  • difficult or troubled breathing
  • difficult, fast, noisy breathing
  • dizziness
  • eye pain
  • fainting
  • fast heartbeat
  • fever
  • general feeling of illness
  • headache
  • hostility
  • increased sweating
  • irregular, fast or slow, or shallow breathing
  • irritability
  • lightheadedness
  • loss of consciousness
  • muscle or joint pain
  • muscle twitching
  • nausea
  • pale skin
  • rapid weight gain
  • rapid, shallow breathing
  • seizures
  • severe sleepiness
  • sore throat
  • swelling around the neck, groin, or underarm area
  • swelling of the arms, feet, or lower legs
  • swelling of the face, ankles, or hands
  • unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness
  • yellow skin or eyes

Some side effects of enasidenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to enasidenib: oral tablet


The most common (30% or more) adverse reactions of any grade were elevated bilirubin, decreased calcium and potassium levels, nausea, diarrhea, vomiting, and decreased appetite.[Ref]


Very common (10% or more): Increased total bilirubin (81%)[Ref]


Very common (10% or more): Decreased calcium (74%), decreased potassium (41%), decreased appetite (34%), decreased phosphorus (27%)
Common (1% to 10%): Tumor lysis syndrome, decreased weight[Ref]


Very common (10% or more): Nausea (50%), diarrhea (43%), vomiting (34%)
Common (1% to 10%): Abdominal pain[Ref]


Very common (10% or more): Differentiation syndrome (14%), noninfectious leukocytosis (12%)[Ref]

Nervous system

Very common (10% or more): Dysgeusia (12%)[Ref]


Common (1% to 10%): Rash[Ref]


Common (1% to 10%): Increased uric acid[Ref]


Common (1% to 10%): Pyrexia, peripheral edema[Ref]


Common (1% to 10%): Renal insufficiency[Ref]


Common (1% to 10%): Respiratory failure, dyspnea, hypoxia, pulmonary edema, acute respiratory distress syndrome[Ref]


1. "Product Information. Idhifa (enasidenib)." Celgene Corporation, Summit, NJ.

Some side effects of Idhifa may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.