Idhifa Side Effects

Generic name: enasidenib

Medically reviewed by Drugs.com. Last updated on Sep 21, 2024.

Note: This document provides detailed information about Idhifa Side Effects associated with enasidenib. Some dosage forms listed on this page may not apply specifically to the brand name Idhifa.

Applies to enasidenib: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Patients treated with enasidenib have experienced symptoms of differentiation syndrome, which can be fatal if not treated.

If differentiation syndrome is suspected, initiate corticosteroid therapy and hemodynamic monitoring until symptom resolution.Early recognition and aggressive management of differentiation syndrome is required to lessen the likelihood of serious illness and death.

Symptoms of differentiation syndrome should be described to patients when starting therapy and at follow-up visits.

Differentiation syndrome has occurred as early as 10 days and up to 5 months after initiating therapy.

Serious side effects of Idhifa

Along with its needed effects, enasidenib (the active ingredient contained in Idhifa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enasidenib:

More common side effects

• agitation
• blue lips, fingernails, or skin
• bone pain
• chest pain
• chills
• confusion
• cough
• coughing that sometimes produces a pink frothy sputum
• decreased awareness or responsiveness
• decreased urine output
• depression
• difficult or troubled breathing
• difficult, fast, noisy breathing
• dizziness
• eye pain
• fainting
• fast heartbeat
• fever
• general feeling of illness
• headache
• hostility
• increased sweating
• irregular, fast or slow, or shallow breathing
• irritability
• lightheadedness
• loss of consciousness
• muscle or joint pain
• muscle twitching
• nausea
• pale skin
• rapid weight gain
• rapid, shallow breathing
• seizures
• severe sleepiness
• sore throat
• swelling around the neck, groin, or underarm area
• swelling of the arms, feet, or lower legs
• swelling of the face, ankles, or hands
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• yellow skin or eyes

Other side effects of Idhifa

Some side effects of enasidenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• change in taste
• decreased appetite
• diarrhea
• loss of taste
• vomiting

For healthcare professionals

Applies to enasidenib: oral tablet.

General adverse events

The most common (30% or more) adverse reactions of any grade were elevated bilirubin, decreased calcium and potassium levels, nausea, diarrhea, vomiting, and decreased appetite.^[Ref]

Hepatic

• Very common (10% or more): Increased total bilirubin (81%)^[Ref]

Metabolic

• Very common (10% or more): Decreased calcium (74%), decreased potassium (41%), decreased appetite (34%), decreased phosphorus (27%)
• Common (1% to 10%): Tumor lysis syndrome, decreased weight^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (50%), diarrhea (43%), vomiting (34%)
• Common (1% to 10%): Abdominal pain^[Ref]

Hematologic

• Very common (10% or more): Differentiation syndrome (14%), noninfectious leukocytosis (12%)^[Ref]

Nervous system

• Very common (10% or more): Dysgeusia (12%)^[Ref]

Dermatologic

• Common (1% to 10%): Rash^[Ref]

Genitourinary

• Common (1% to 10%): Increased uric acid^[Ref]

Other

• Common (1% to 10%): Pyrexia, peripheral edema^[Ref]

Renal

• Common (1% to 10%): Renal insufficiency^[Ref]

Respiratory

• Common (1% to 10%): Respiratory failure, dyspnea, hypoxia, pulmonary edema, acute respiratory distress syndrome^[Ref]

Frequently asked questions

• How long does it take for Idhifa to start working?
• How does Idhifa work in acute myeloid leukemia (AML)?
• Can Idhifa cause differentiation syndrome?
• What is Idhifa used to treat?

Further information

Idhifa side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer