IDHIFA Dosage

Generic name: ENASIDENIB MESYLATE 50mg
Dosage form: tablet, film coated
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com. Last updated on Jan 16, 2025.

Select patients for the treatment of AML with IDHIFA based on the presence of IDH2 mutations in the blood or bone marrow.

Interrupt dosing or reduce dose for toxicities. See Table 1 for dosage modification guidelines.

Table 1: Dosage Modifications for IDHIFA-Related Toxicities
*Grade 1 is mild, Grade 2 is moderate, Grade 3 is serious, Grade 4 is life-threatening.
Adverse Reaction	Recommended Action
• Differentiation syndrome	• If differentiation syndrome is suspected, administer systemic corticosteroids and initiate hemodynamic monitoring. • Interrupt IDHIFA if severe pulmonary symptoms requiring intubation or ventilator support, and/or renal dysfunction persist for more than 48 hours after initiation of corticosteroids. • Resume IDHIFA when signs and symptoms improve to Grade 2* or lower.
• Noninfectious leukocytosis (white blood cell [WBC] count greater than 30 × 109/L)	• Initiate treatment with hydroxyurea, as per standard institutional practices. • Interrupt IDHIFA if leukocytosis is not improved with hydroxyurea, and then resume IDHIFA at 100 mg daily when WBC is less than 30 × 109/L.
• Elevation of bilirubin greater than 3 times the upper limit of normal (ULN) sustained for ≥2 weeks without elevated transaminases or other hepatic disorders	• Reduce IDHIFA dose to 50 mg daily. • Resume IDHIFA at 100 mg daily if bilirubin elevation resolves to less than 2 × ULN.
• Other Grade 3* or higher toxicity considered related to treatment including tumor lysis syndrome	• Interrupt IDHIFA until toxicity resolves to Grade 2* or lower. • Resume IDHIFA at 50 mg daily; may increase to 100 mg daily if toxicities resolve to Grade 1* or lower. • If Grade 3* or higher toxicity recurs, discontinue IDHIFA.