Extina Side Effects

Generic name: ketoconazole topical

Medically reviewed by Drugs.com. Last updated on Nov 28, 2023.

Note: This document provides detailed information about Extina.

Applies to ketoconazole topical: topical cream, topical foam, topical gel/jelly, topical shampoo Side Effects associated with ketoconazole topical. Some dosage forms listed on this page may not apply specifically to the brand name Extina.

Applies to ketoconazole topical: topical cream, topical foam, topical gel/jelly, topical shampoo.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and check you for any problems or unwanted effects that may be caused by this medicine.

Do not use this medicine for a skin problem that has not been checked by your doctor.

If your skin problem does not improve within 2 weeks for cutaneous candidiasis, pityriasis versicolor, tinea corporis, or tinea cruris; or 4 weeks for seborrheic dermatitis; or 4 to 6 weeks for tinea pedis, or if it becomes worse, check with your doctor.

Good health habits are also required for patients using the cream form of this medicine to help clear up your infection completely and to help make sure it does not return.

For patients using the cream for athlete's foot (tinea pedis; ringworm of the foot), the following instructions will help keep the feet cool and dry:

• Avoid wearing socks made from wool or synthetic materials (e.g., rayon or nylon). Instead, wear clean, cotton socks and change them daily or more often if your feet sweat a lot.
• Wear sandals or well-ventilated shoes (e.g., shoes with holes).
• Use a bland, absorbent powder (e.g., talcum powder) or an antifungal powder between the toes, on the feet, and in socks and shoes one or two times a day. It is best to use the powder between the times you use the cream.
• If you have any questions about these instructions, check with your doctor.

For patients using the cream for ringworm of the groin (tinea cruris; jock itch), the following instructions will help reduce chafing and irritation and will also help keep the groin area cool and dry:

• Avoid wearing underwear that is tight-fitting or made from synthetic materials (e.g., rayon or nylon). Instead, wear loose-fitting, cotton underwear.
• Use a bland, absorbent powder (e.g., talcum powder) or an antifungal powder on the skin. It is best to use the powder between the times you use ketoconazole cream.
• If you have any questions about these instructions, check with your doctor.

The foam form of this medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Tell your doctor if you have the following symptoms while using the ketoconazole 2% shampoo: hair discoloration, abnormal hair texture, removal of the curl from permanently waved hair, hair loss, itching, burning sensation of the skin, or blistering, peeling, or redness of the skin.

Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Serious side effects of Extina

Along with its needed effects, ketoconazole topical (the active ingredient contained in Extina) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ketoconazole topical:

Less common—For cream, shampoo, foam, or gel

• Itching, stinging, burning, or irritation not present before use of this medicine

Rare—For cream, foam, or gel

• Acne
• bleeding from sore in the mouth
• blistering, crusting, irritation, itching, or reddening of the skin
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• cracked, dry, or scaly skin
• discoloration of the fingernails or toenails
• dizziness
• eye dryness, irritation, or swelling
• red rash with watery, yellow-colored, or pus filled blisters with or without thick yellow to honey-colored crusts
• skin dryness, pain, rash, redness, or swelling
• sore in the mouth or on the gums
• swelling of the face

Rare—For shampoo

• Hair loss and irritation

Incidence not known—For gel

• Pain

Incidence not known—For shampoo

• Blistering, burning, crusting, dryness, or flaking of the skin
• burning sensation of the skin
• burning, itching, redness, skin rash, swelling, or soreness at the application site
• discoloration of the hair
• dry skin
• fast heartbeat
• fever
• hives
• hoarseness
• irritation
• itching, scaling, severe redness, or soreness of the skin
• joint pain, stiffness, or swelling
• rash
• shortness of breath
• swelling of the eyelids, face, lips, hands, or feet
• thinning of the hair
• tightness in the chest
• troubled breathing or swallowing
• wheezing

Other side effects of Extina

Some side effects of ketoconazole topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common—For shampoo or gel

• Dryness or oiliness of the hair and scalp
• headache

Rare—For shampoo

• Abnormal hair texture
• mild dryness of the skin
• scalp pustules

For healthcare professionals

Applies to ketoconazole topical: topical cream, topical foam, topical gel, topical kit, topical shampoo.

Dermatologic adverse events

Cream:

• Common (1% to 10%): Skin burning sensation
• Uncommon (0.1% to 1%): Bullous eruption, contact dermatitis, rash, skin exfoliation, sticky skin
• Frequency not reported: Severe irritation, pruritus, stinging, urticaria

Foam:

• Frequency not reported: Reactions to a photoallergenicity study, contact sensitization
• Postmarketing reports: Skin burning sensation, erythema

Gel:

• Frequency not reported: Impetigo, pyogenic granuloma, acne, nail discoloration

Shampoo:

• Uncommon (0.1% to 1%): Alopecia, dry skin, abnormal hair texture, rash, skin burning sensation, folliculitis
• Rare (0.01% to 0.1%): Acne, contact dermatitis, skin disorder, skin exfoliation
• Frequency not reported: Normal hair loss increased, irritation, scalp pustules, mild skin dryness, oiliness/dryness of hair and scalp, pruritus
• Postmarketing reports: Hair discoloration/hair color changes, itching, angioedema, urticaria, skin irritation^[Ref]

Rare reports of contact dermatitis have been associated with the cream or 1 of its excipients (i.e., sodium sulfite or propylene glycol) during postmarketing experience.

Alopecia, dry skin, abnormal hair texture, rash, skin burning sensation, and contact dermatitis have also been reported during postmarketing experience with the shampoo.^[Ref]

Local

Cream:

• Common (1% to 10%): Application site pruritus, application site erythema
• Uncommon (0.1% to 1%): Application site bleeding, application site discomfort, application site dryness, application site inflammation, application site irritation, application site paresthesia, application site reaction

Foam:

• Common (1% to 10%): Application site burning, application site reaction
• Frequency not reported: Application site reactions (dryness, erythema, irritation, paresthesia, pruritus, rash, warmth)
• Postmarketing reports: Application site pain, application site burn

Gel:

• Common (1% to 10%): Application site burning
• Frequency not reported: Treatment-related application site reactions (dermatitis, discharge, dryness, erythema, irritation, pain, pruritus, pustules)
• Postmarketing reports: Burning sensation, pain, skin irritation, erythema

Shampoo:

• Uncommon (0.1% to 1%): Application site erythema, application site irritation, application site pruritus, application site reaction
• Rare (0.01% to 0.1%): Application site hypersensitivity, application site pustules

Application site reactions have also been reported during postmarketing experience with the shampoo.

Hypersensitivity

Cream:

• Uncommon (0.1% to 1%): Hypersensitivity
• Frequency not reported: Painful allergic reaction

Shampoo:

• Rare (0.01% to 0.1%): Hypersensitivity
• Postmarketing reports: Hypersensitivity reactions (including anaphylaxis)^[Ref]

Nervous system

Gel:

• Frequency not reported: Headache, dizziness, paresthesia

Shampoo:

• Rare (0.01% to 0.1%): Dysgeusia

Ocular

Gel:

• Frequency not reported: Eye irritation, eye swelling, keratoconjunctivitis sicca

Shampoo:

• Uncommon (0.1% to 1%): Increased lacrimation
• Rare (0.01% to 0.1%): Eye irritation

Other

Gel:

• Frequency not reported: Facial swelling

Shampoo:

• Frequency not reported: Removal of curl from permanently waved hair

Gastrointestinal

Foam:

• Postmarketing reports: Cheilitis

See also:

Further information

Extina side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer