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Dutasteride Side Effects

For the Consumer

Applies to dutasteride: oral capsule liquid filled

In addition to its needed effects, some unwanted effects may be caused by dutasteride. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking dutasteride:

Rare:
  • Chest pain or discomfort
  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • shortness of breath
  • swelling of the face, fingers, feet, or lower legs
  • weight gain
  • wheezing
Incidence not known:
  • Blistering, flaking, or peeling of the skin
  • cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives or welts
  • itching skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

Severity: Minor

Some of the side effects that can occur with dutasteride may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Abnormal ejaculation
  • decreased interest in sexual intercourse
  • decreased sexual performance or desire
  • impotence
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • pain, soreness, swelling, or discharge from the breast or breasts

For Healthcare Professionals

Applies to dutasteride: oral capsule

Other

Common (1% to 10%): Impotence, decreased libido, ejaculation disorders, breast disorders
Postmarketing reports: Testicular pain and swelling[Ref]

-Impotence, decreased libido, and ejaculation disorders may persist after treatment discontinuation; this drug's role in this persistence is unknown.
-Ejaculation disorders included anorgasmia, retrograde ejaculation, decreased semen volume, decreased orgasmic sensation, abnormal orgasm, delayed ejaculation, ejaculation failure, and premature ejaculation.
-Breast disorders include breast enlargement, gynecomastia, breast swelling, breast pain, breast tenderness, nipple pain, and nipple swelling.[Ref]

Oncologic

Common (1% to 10%): High-grade prostate cancer
Frequency not reported: Male breast cancer[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Cardiac failure[Ref]

Dermatologic

Uncommon (0.1% to 1%): Alopecia (primarily body hair loss), hypertrichosis[Ref]

Nervous system

Uncommon (0.1% to 1%): Dizziness, nervous system disorders[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity reactions (e.g., rash, pruritus, urticaria, localized edema, serious skin reactions, angioedema)[Ref]

Psychiatric

Postmarketing reports: Depressed mood[Ref]

References

1. "Product Information. Duagen (dutasteride)." GlaxoSmithKline Healthcare, Pittsburgh, PA.

Not all side effects for dutasteride may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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