Skip to Content

Duradal HD Side Effects

Generic Name: chlorpheniramine / hydrocodone / phenylephrine

Note: This document contains side effect information about chlorpheniramine / hydrocodone / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name Duradal HD.

For the Consumer

Applies to chlorpheniramine / hydrocodone / phenylephrine: oral liquid

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medications, hydrocodone can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop taking this medicine and call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing;

  • a slow heart rate or weak pulse;

  • nervousness, trouble sleeping;

  • severe constipation; or

  • little or no urination.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Common side effects may include:

  • drowsiness; or

  • feeling restless or excited (especially in children).

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to chlorpheniramine/hydrocodone/phenylephrine: oral liquid, oral syrup


Cardiovascular side effects have included hypertension, postural hypotension, tachycardia, and palpitations.[Ref]


Genitourinary side effects have included ureteral spasm, spasm of vesical sphincters, and urinary retention.[Ref]

Nervous system

Nervous system side effects have included sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, and dizziness.[Ref]


Psychiatric side effects have included psychic dependence and mood changes.[Ref]


Ocular side effects have included blurred vision.[Ref]


Gastrointestinal side effects have included nausea and vomiting.[Ref]


1. "Product Information. Tusana-D (chlorpheniramine / hydrocodone / phenylephrine)." Cypress Pharmaceutical Inc, Madison, MS.

Some side effects of Duradal HD may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about Duradal HD (chlorpheniramine / hydrocodone / phenylephrine)

Consumer resources

Other brands: Relasin-HC, Triant-HC, B-Tuss, De-Chlor HC, ... +5 more

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.