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Desmopressin Side Effects

Medically reviewed by Last updated on Jun 26, 2021.

In Summary

More frequently reported side effects include: headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to desmopressin: oral tablet

Other dosage forms:

Side effects requiring immediate medical attention

Along with its needed effects, desmopressin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desmopressin:


Incidence not known

  • Weight gain

Side effects not requiring immediate medical attention

Some side effects of desmopressin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to desmopressin: injectable solution, nasal solution, nasal spray, oral tablet, sublingual tablet


One review of the literature found that the incidence of thrombotic events associated with the use of DDAVP to reduce blood loss and transfusion requirements in surgical patients was not significantly higher than placebo. In any case, the incidence of thrombosis is rare. One review found only 10 reports of thrombosis over a 4-year period, covering 433,000 doses of DDAVP.[Ref]

Cardiovascular side effects have infrequently included transient and slight elevations or reductions in blood pressure, a compensatory change in heart rate, and facial flushing with injections of desmopressin (DDAVP). Vasodilation and water retention have occurred. There have been rare reports of thrombotic events (acute cerebral thrombosis, acute myocardial infarction) in some patients after DDAVP injection. At least one case of fatal left coronary thrombosis has been associated with the use of DDAVP.[Ref]

Nervous system

Nervous system side effects have included seizures and/or coma as a result of severe water intoxication and hyponatremia. Other nervous system side effects have included headache and dizziness in less than 3% of patients. DDAVP nasal spray has been infrequently associated with somnolence, lethargy, paresthesias, fatigue, confusion, stupor, malaise, diaphoresis, itchy or light-sensitive eyes, insomnia, chills, warm feeling, and agitation.[Ref]

The risk factors for DDAVP-induced hyponatremia include stress, surgery, anesthesia, narcotics (endogenous release of ADH), vomiting (loss of sodium), liver disease (hindered metabolism of DDAVP), overhydration with hyponatremic fluids, and advanced age. In some cases, fluid restriction, avoidance of hyponatremic solutions, and close monitoring of serum electrolytes and urine output for at least 15 to 20 hours after the administration of DDAVP may be beneficial.[Ref]


Hematologic side effects have included platelet aggregation and thrombocytopenia. These have been seen almost uniquely in patients with von Willebrand's disease Type IIB (DDAVP is contraindicated in these patients).[Ref]


Local side effects of injections of DDAVP have included intravenous site erythema, swelling, and burning.[Ref]


Respiratory side effects of intranasal DDAVP have included rhinitis, epistaxis, and nostril pain in 2% to 10% of patients. Apnea and cardiac arrest occurred in one patient.[Ref]


Gastrointestinal side effects have included mild abdominal cramps and nausea in 2% of patients. Dyspepsia and vomiting have rarely been associated with DDAVP nasal spray.[Ref]


Hypersensitivity reactions have rarely included anaphylaxis.[Ref]


Psychiatric side effects have included a single case of paranoid psychosis associated with the use of DDAVP nasal spray.[Ref]

Frequently asked questions


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2. Albert SG, Salvato-Lechner V, Joist JH "Venous thromboembolism and transient thrombocytopenia in a patient with diabetes insipidus treated with desmopressin acetate (DDAVP)." Thromb Res 50 (1988): 695-705

3. Mannucci PM, Carlsson S, Harris AS "Desmopressin, surgery and thrombosis." Thromb Haemost 71 (1994): 154-5

4. Bond L, Bevan D "Myocardial infarction in a patient with hemophilia treated with DDAVP." N Engl J Med 318 (1988): 121

5. Brommer EJ, van Brummelen P, Derkx FH "Desmopressin and hypotension." Ann Intern Med 103 (1985): 962

6. Vermylen J, Peerlinck K "Fatal complication of desmopressin." Lancet 346 (1995): 447

7. D'Alauro FS, Johns RA "Hypotension related to desmopressin administration following cardiopulmonary bypass." Anesthesiology 69 (1988): 962-3

8. Shulman LH, Miller JL, Rose LI "Desmopressin for diabetes insipidus, hemostatic disorders and enuresis." Am Fam Physician 42 (1990): 1051-7

9. Vigano GL, Mannucci PM, Lattuada A, Harris A, Remuzzi G "Subcutaneous desmopressin (DDAVP) shortens the bleeding time in uremia." Am J Hematol 31 (1989): 32-5

10. Lowe GD "Desmopressin and myocardial infarction." Lancet 1 (1989): 895-6

11. Hartmann S "Fatal complication of desmopressin - reply." Lancet 346 (1995): 447

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14. McLeod BC "Myocardial infarction in a blood donor after administration of desmopressin." Lancet 336 (1990): 1137-8

15. Miller K, Atkin B, Moody ML "Drug therapy for nocturnal enuresis. Current treatment recommendations." Drugs 44 (1992): 47-56

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18. Harris AS "Clinical experience with desmopressin: efficacy and safety in central diabetes insipidus and other conditions." J Pediatr 114 (1989): 711-8

19. Sun HL, Chien CC "Thrombocytopenia and subdural hemorrhage after desmopressin administration." Anesthesiology 88 (1998): 1115-7

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21. "Product Information. DDAVP (desmopressin)." Rhone-Poulenc Rorer, Collegeville, PA.

22. Salva KM, Kim HC, Nahum K, Fallot PL "DDAVP in the treatment of bleeding disorders." Pharmacotherapy 8 (1988): 94-9

23. Israels SJ, Kobrinsky NL "Serious reaction to desmopressin in a child with cyanotic heart disease." N Engl J Med 320 (1989): 1563-4

24. Smith TJ, Gill JC, Ambruso DR, Hathaway WE "Hyponatremia and seizures in young children given DDAVP." Am J Hematol 31 (1989): 199-202

25. Robson WLM, Norgaard JP, Leung AKC "Hyponatremia in patients with nocturnal enuresis treated with DDAVP." Eur J Pediatr 155 (1996): 959-62

26. Sukhai RN "Enuresis nocturna: long term use and safety aspects of minrin (desmopressin) spray." Regul Pept 45 (1993): 309-10

27. Stenberg A, Lackgren G "Desmopressin tablets in the treatment of severe nocturnal enuresis in adolescents." Pediatrics 94 (1994): 841-6

28. Williford SL "Water intoxication in patients treated with desmopressin - reply." Pharmacotherapy 16 (1996): 970

29. Schwab M, Wenzel D, Ruder H "Hyponatraemia and cerebral convulsion due to short term DDAVP therapy for control of enuresis nocturna." Eur J Pediatr 155 (1996): 46-8

30. Beach PS, Beach RE, Smith LR "Hyponatremic seizures in a child treated with desmopressin to control enuresis. A rational approach to fluid intake." Clin Pediatr (Phila) 31 (1992): 566-9

31. Yaouyanc G, Jonville AP, Yaouyanc-Lapalle H, Barbier P, Dutertre JP, Autret E "Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis." J Toxicol Clin Toxicol 30 (1992): 637-41

32. Humphries JE, Siragy H "Significant hyponatremia following DDAVP administration in a healthy adult." Am J Hematol 44 (1993): 12-5

33. Asplund R, Aberg H "Desmopressin in elderly women with increased nocturnal diuresis. A short-term study." Br J Urol 72 (1993): 42-5

34. Simmonds EJ, Mahony MJ, Little JM "Convulsion and coma after intranasal desmopressin in cystic fibrosis." BMJ 297 (1988): 1614

35. Hourihane J, Salisbury AJ "Use caution in prescribing desmopressin for nocturnal enuresis." BMJ 306 (1993): 1545

36. Odeh M, Oliven A "Coma and seizures due to severe hyponatremia and water intoxication in an adult with intranasal desmopressin therapy for nocturnal enuresis." J Clin Pharmacol 41 (2001): 582-4

37. Shepherd LL, Hutchinson RJ, Worden EK, Koopmann CF, Coran A "Hyponatremia and seizures after intravenous administration of desmopressin acetate for surgical hemostasis." J Pediatr 114 (1989): 470-2

38. Kallio J, Rautava P, Huupponen R, Korvenranta H "Severe hyponatremia caused by intranasal desmopressin for nocturnal enuresis." Acta Paediatr 82 (1993): 881-2

39. Hamed M, Mitchell H, Clow DJ "Hyponatraemic convulsion associated with desmopressin and imipramine treatment." BMJ 306 (1993): 1169

40. Williford SL, Bernstein SA "Intranasal desmopressin-induced hyponatremia." Pharmacotherapy 16 (1996): 66-74

41. Robson WLM "Water intoxication in patients treated with desmopressin." Pharmacotherapy 16 (1996): 969-70

42. Weinstein RE, Bona RD, Altman AJ, Quinn JJ, Weisman SJ, Bartolomeo A, Rickles FR "Severe hyponatremia after repeated intravenous administration of desmopressin." Am J Hematol 32 (1989): 258-61

43. Sweeney JD, Hoernig LA, Behrens AN, Novak E, Swank RT "von Willebrand's variant (type II Buffalo). Thrombocytopenia after desmopressin but absence of in vitro hypersensitivity to ristocetin." Am J Clin Pathol 93 (1990): 522-5

44. Holmberg L, Nilsson IM, Borge L, Gunnarsson M, Sjorin E "Platelet aggregation induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in Type IIB von Willebrand's disease." N Engl J Med 309 (1983): 816-21

45. Castaman G, Rodeghiero F, Lattuada A, Mannucci PM "Desmopressin-induced thrombocytopenia in type I platelet discordant von Willebrand disease." Am J Hematol 43 (1993): 5-9

46. Itabashi A, Katayama S, Yamaji T "Hypersensitivity to chlorobutanol in DDAVP solution." Lancet 1 (1982): 108

47. Collins GB, Marzewski DJ, Rollins MB "Paranoid psychosis after DDAVP therapy for Alzheimer's dementia." Lancet 2 (1981): 808

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.