Cytomegalovirus immune globulin Side Effects
For the Consumer
Applies to cytomegalovirus immune globulin: parenteral injection for iv infusion
Side effects include:
Flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, wheezing/shortness of breath/chest tightness.
For Healthcare Professionals
Applies to cytomegalovirus immune globulin: intravenous solution
The most frequent side effects have included minor reactions such as flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, and wheezing in < 6.0% of all infusions. These reactions were most often related to the infusion rate. A decrease in blood pressure was observed in 1 of 1039 infusions in clinical trials. If a minor reaction occurs, the infusion should be slowed or temporarily interrupted.[Ref]
Renal side effects have included increases in serum creatinine and blood urea nitrogen (BUN) within 1 to 2 days after IGIV infusion, oliguria or anuria requiring dialysis, acute renal failure, acute tubular necrosis, proximal tubular nephropathy, and osmotic nephrosis.[Ref]
Cardiovascular side effects have included cardiac arrest, thromboembolism, vascular collapse, and hypotension.[Ref]
Dermatologic side effects have included Stevens-Johnson syndrome, epidermolysis, erythema multiforme, and bullous dermatitis.[Ref]
Gastrointestinal side effects have included abdominal pain.[Ref]
Hematologic side effects have included pancytopenia, leukopenia, hemolysis, and positive direct antiglobulin (Coombs) test.[Ref]
Hepatic side effects have included hepatic dysfunction.[Ref]
Hypersensitivity reactions including angioneurotic edema and anaphylactic shock may occur. Clinical anaphylaxis may occur even when the patient is not known to be sensitized to immune globulin products. A reaction may be related to the rate of infusion.[Ref]
Musculoskeletal side effects have included back pain.[Ref]
Nervous system side effects have included coma, loss of consciousness, seizures, and tremor.[Ref]
Respiratory side effects have included apnea, acute respiratory distress syndrome (ARDS), transfusion associated lung injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, and bronchospasm.[Ref]
Other side effects have included pyrexia and rigors.[Ref]
1. "Product Information. Cytogam (cytomegalovirus immune globulin)." Medimmune Inc, Gaithersburg, MD.
Not all side effects for cytomegalovirus immune globulin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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- Drug class: immune globulins
Other brands: CytoGam
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