Skip to main content

Cytomegalovirus Immune Globulin Dosage

Medically reviewed by Drugs.com. Last updated on Mar 3, 2022.

Applies to the following strengths: 50 mg/mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for CMV Prophylaxis

Kidney transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 100 mg/kg
4 weeks post transplant: 100 mg/kg
6 weeks post transplant: 100 mg/kg
8 weeks post transplant: 100 mg/kg
12 weeks post transplant: 50 mg/kg
16 weeks post transplant: 50 mg/kg
Maximum dose: 150 mg immunoglobulin/kg


Liver, pancreas, lung, or heart transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 150 mg/kg
4 weeks post transplant: 150 mg/kg
6 weeks post transplant: 150 mg/kg
8 weeks post transplant: 150 mg/kg
12 weeks post transplant: 100 mg/kg
16 weeks post transplant: 100 mg/kg
Maximum dose: 150 mg immunoglobulin/kg

Comments:
-In organ transplants other than kidney from cytomegalovirus seropositive donors into seronegative recipients, consider using prophylactically in combination with ganciclovir.

Use: Prophylaxis of cytomegalovirus disease associated with transplantation of kidney, lung, liver, pancreas, and heart

Usual Pediatric Dose for CMV Prophylaxis

Kidney transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 100 mg/kg
4 weeks post transplant: 100 mg/kg
6 weeks post transplant: 100 mg/kg
8 weeks post transplant: 100 mg/kg
12 weeks post transplant: 50 mg/kg
16 weeks post transplant: 50 mg/kg
Maximum dose: 150 mg immunoglobulin/kg


Liver, pancreas, lung, or heart transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 150 mg/kg
4 weeks post transplant: 150 mg/kg
6 weeks post transplant: 150 mg/kg
8 weeks post transplant: 150 mg/kg
12 weeks post transplant: 100 mg/kg
16 weeks post transplant: 100 mg/kg
Maximum dose: 150 mg immunoglobulin/kg

Comments:
-In organ transplants other than kidney from cytomegalovirus seropositive donors into seronegative recipients, consider using prophylactically in combination with ganciclovir.

Use: Prophylaxis of cytomegalovirus disease associated with transplantation of kidney, lung, liver, pancreas, and heart

Renal Dose Adjustments

Use with caution.
-Administer at the minimum concentration and minimum infusion rate practicable.
-Consider discontinuation if renal function deteriorates.
-Make sure patients are not volume depleted prior to infusion.

Liver Dose Adjustments

Data not available

Dose Adjustments

Minor side effects: Slow the administration rate immediately; consider temporary interruption of the infusion.

Precautions

CONTRAINDICATIONS:
-History of severe reactions to this or other human immunoglobulin preparations
-Selective immunoglobulin A deficiency patients have the potential for developing antibodies and could have an anaphylactic reaction to subsequent doses of immunoglobulin A containing products.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Only for intravenous administration.
-Initial dose should be administered at 15 mg/kg/hour; if no adverse reactions after 30 minutes, may increase to 30 mg/kg/hour; if no adverse reactions after another 30 minutes, may increase to 60 mg/kg/hour.
-Subsequent doses should be administered at 15 mg/kg/hour; if no adverse reactions after 15 minutes, may increase to 60 mg/kg/hour.
-Maximum administration rate: 75 mL/hour

Storage requirements:
-Refrigerate

Reconstitution/preparation techniques:
-Do not shake vial; avoid foaming
-Infusion should start within 6 hours of entering the vial and should be completed within 12 hours of entering the vial.

Monitoring:
-Take vital signs pre-infusion, midway, and post-infusion, as well as before any rate increase.
-Monitor closely during and after each rate change.

More about cytomegalovirus immune globulin

Patient resources

Other brands
CytoGam

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.