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Cytomegalovirus Immune Globulin Dosage

Applies to the following strength(s): 50 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for CMV Prophylaxis

Kidney transplant:
Within 72 hours of transplant: 150 mg/kg
2 to 8 weeks post transplant: 100 mg/kg
12 to 16 weeks post transplant: 50 mg/kg

Liver, pancreas, lung, heart transplant:
Within 72 hours of transplant: 150 mg/kg
2 to 8 weeks post transplant: 150 mg/kg
12 to 16 weeks post transplant: 100 mg/kg

Administer IV at 15 mg/kg/hour. If no adverse reactions occur after 30 minutes, the rate may be increased to 30 mg/kg/hour for 15 minutes before increasing to a maximum rate of 60 mg/kg/hour. Maximum volume not to exceed 75 mL/hr.

The maximum recommended total dosage per infusion is 150 mg/kg.

Usual Pediatric Dose for CMV Prophylaxis

Kidney transplant:
Within 72 hours of transplant: 150 mg/kg
2 to 8 weeks post transplant: 100 mg/kg
12 to 16 weeks post transplant: 50 mg/kg

Liver, pancreas, lung, heart transplant:
Within 72 hours of transplant: 150 mg/kg
2 to 8 weeks post transplant: 150 mg/kg
12 to 16 weeks post transplant: 100 mg/kg

Administer IV at 15 mg/kg/hour. If no adverse reactions occur after 30 minutes, the rate may be increased to 30 mg/kg/hour for 15 minutes before increasing to a maximum rate of 60 mg/kg/hour.

The maximum recommended total dosage per infusion is 150 mg/kg.

Renal Dose Adjustments

Cytomegalovirus immune globulin (CMV-IGIV) should be used with caution in patients with renal impairment or patients at risk for development of renal impairment. Do not exceed an infusion rate of 60 mg/kg/hour (maximum volume 75 mL/hour).

If renal function deteriorates, discontinuation of CMV-IGIV should be considered.

Most cases of renal insufficiency have occurred in patients receiving total doses of 350 mg/kg or greater.

Liver Dose Adjustments

No adjustment recommended.

Dose Adjustments

If a patient develops a minor side effect (e.g., flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, or wheezing), the infusion should be slowed immediately or temporarily interrupted.

Precautions

Epinephrine and diphenhydramine should be available for treatment of acute allergic reactions and the infusion should be stopped immediately.

Patients should not be volume depleted when receiving CMV-IGIV.

Dialysis

Caution is recommended in patients with renal insufficiency.

Other Comments

CMV-IGIV does not contain a preservative. The vial should be entered only once for administration purposes and the infusion should begin within 6 hours.

In organ transplants other than kidney from CMV seropositive donors into seronegative recipients, CMV-IGIV should be considered in combination with ganciclovir.

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