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Cytomegalovirus Immune Globulin Dosage

Medically reviewed on March 13, 2018.

Applies to the following strengths: 50 mg/mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for CMV Prophylaxis

Kidney transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 100 mg/kg
4 weeks post transplant: 100 mg/kg
6 weeks post transplant: 100 mg/kg
8 weeks post transplant: 100 mg/kg
12 weeks post transplant: 50 mg/kg
16 weeks post transplant: 50 mg/kg
Maximum dose: 150 mg immunoglobulin/kg


Liver, pancreas, lung, or heart transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 150 mg/kg
4 weeks post transplant: 150 mg/kg
6 weeks post transplant: 150 mg/kg
8 weeks post transplant: 150 mg/kg
12 weeks post transplant: 100 mg/kg
16 weeks post transplant: 100 mg/kg
Maximum dose: 150 mg immunoglobulin/kg

Comments:
-In organ transplants other than kidney from cytomegalovirus seropositive donors into seronegative recipients, consider using prophylactically in combination with ganciclovir.

Use: Prophylaxis of cytomegalovirus disease associated with transplantation of kidney, lung, liver, pancreas, and heart

Usual Pediatric Dose for CMV Prophylaxis

Kidney transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 100 mg/kg
4 weeks post transplant: 100 mg/kg
6 weeks post transplant: 100 mg/kg
8 weeks post transplant: 100 mg/kg
12 weeks post transplant: 50 mg/kg
16 weeks post transplant: 50 mg/kg
Maximum dose: 150 mg immunoglobulin/kg


Liver, pancreas, lung, or heart transplant:
Within 72 hours of transplant: 150 mg/kg
2 weeks post transplant: 150 mg/kg
4 weeks post transplant: 150 mg/kg
6 weeks post transplant: 150 mg/kg
8 weeks post transplant: 150 mg/kg
12 weeks post transplant: 100 mg/kg
16 weeks post transplant: 100 mg/kg
Maximum dose: 150 mg immunoglobulin/kg

Comments:
-In organ transplants other than kidney from cytomegalovirus seropositive donors into seronegative recipients, consider using prophylactically in combination with ganciclovir.

Use: Prophylaxis of cytomegalovirus disease associated with transplantation of kidney, lung, liver, pancreas, and heart

Renal Dose Adjustments

Use with caution.
-Administer at the minimum concentration and minimum infusion rate practicable.
-Consider discontinuation if renal function deteriorates.
-Make sure patients are not volume depleted prior to infusion.

Liver Dose Adjustments

Data not available

Dose Adjustments

Minor side effects: Slow the administration rate immediately; consider temporary interruption of the infusion.

Precautions

CONTRAINDICATIONS:
-History of severe reactions to this or other human immunoglobulin preparations
-Selective immunoglobulin A deficiency patients have the potential for developing antibodies and could have an anaphylactic reaction to subsequent doses of immunoglobulin A containing products.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Only for intravenous administration.
-Initial dose should be administered at 15 mg/kg/hour; if no adverse reactions after 30 minutes, may increase to 30 mg/kg/hour; if no adverse reactions after another 30 minutes, may increase to 60 mg/kg/hour.
-Subsequent doses should be administered at 15 mg/kg/hour; if no adverse reactions after 15 minutes, may increase to 60 mg/kg/hour.
-Maximum administration rate: 75 mL/hour

Storage requirements:
-Refrigerate

Reconstitution/preparation techniques:
-Do not shake vial; avoid foaming
-Infusion should start within 6 hours of entering the vial and should be completed within 12 hours of entering the vial.

Monitoring:
-Take vital signs pre-infusion, midway, and post-infusion, as well as before any rate increase.
-Monitor closely during and after each rate change.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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