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Cortomycin Suspension Side Effects

Generic Name: hydrocortisone / neomycin / polymyxin b ophthalmic

Note: This page contains information about the side effects of hydrocortisone / neomycin / polymyxin b ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Cortomycin Suspension.

For the Consumer

Applies to hydrocortisone / neomycin / polymyxin b ophthalmic: ophthalmic suspension

In addition to its needed effects, some unwanted effects may be caused by hydrocortisone / neomycin / polymyxin b ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

Stop taking hydrocortisone / neomycin / polymyxin b ophthalmic and get emergency help immediately if any of the following effects occur:

  • Fainting
  • lightheadedness (sudden and severe)
  • shortness of breath or trouble breathing (severe)
  • swelling around face

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking hydrocortisone / neomycin / polymyxin b ophthalmic:

More common:
  • Itching, rash, redness, swelling, or other sign of irritation not present before use of this medicine
  • Blurred vision or other change in vision
  • delayed healing of eye infection

Minor Side Effects

Some of the side effects that can occur with hydrocortisone / neomycin / polymyxin b ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Burning or stinging when applying medicine

For Healthcare Professionals

Applies to hydrocortisone / neomycin / polymyxin b ophthalmic: ophthalmic suspension


Ocular side effects associated with the corticosteroid component of this drug include increased intraocular pressure with possible development of glaucoma and infrequent optic nerve damage, posterior subcapsular cataract formation, and delayed wound healing have been reported.

Bacterial, fungal, and viral secondary ocular infections, local irritation, visual disturbance (blurry vision) have also been reported with the use of ocular corticosteroids.[Ref]


Hypersensitivity reactions associated with the anti-infective component of this drug include allergic sensitization manifested by itching, swelling, and conjunctival erythema. More serious reactions such as anaphylaxis have rarely been reported.[Ref]

Neomycin is known to cause contact sensitivity.[Ref]


1. "Product Information. Cortisporin Ophthalmic Suspension (hydrocortisone/neomycin/polymyxin B ophth)." Allscripts Pharmaceutical Company, Vernon Hills, IL.

2. Prystowsky SD, Nonomura JH, Smith RW, Allen AM "Allergic hypersensitivity to neomycin. Relationship between patch test reactions and 'use' tests." Arch Dermatol 115 (1979): 713-5

3. Prystowsky SD, Allen AM, Smith RW, Nonomura JH, Odom RB, Akers WA "Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine. Relationships between age, sex, history of exposure, and reactivity to standard patch tests and use tests in a general population." Arch Dermatol 115 (1979): 959-62

Not all side effects for Cortomycin Suspension may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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