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Cinacalcet Side Effects

In Summary

Commonly reported side effects of cinacalcet include: decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cinacalcet: oral tablet

Along with its needed effects, cinacalcet may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cinacalcet:

More common
  • Blurred vision
  • chest pain
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Less common
  • Convulsions
  • cough or hoarseness
  • fever or chills
  • loss of bladder control
  • lower back or side pain
  • muscle spasm or jerking of all extremities
  • painful or difficult urination
  • sudden loss of consciousness
Incidence not known
  • Abdominal or stomach cramps
  • confusion
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • irregular breathing
  • irregular heartbeats
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • low bone turnover
  • mood or mental changes
  • muscle aching or cramping
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pains or stiffness
  • numbness and tingling around the mouth, fingertips, or feet
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen joints
  • tightness in the chest
  • tremor
  • troubled breathing
  • unusual tiredness or weakness
  • weight gain

Some side effects of cinacalcet may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • lack or loss of strength
  • loss of appetite
  • nausea
  • vomiting
  • weight loss
Incidence not known
  • Hives or welts, itching, rash
  • redness of the skin

For Healthcare Professionals

Applies to cinacalcet: oral tablet

Cardiovascular

Very common (10% or more): Hypotension (11.6%)
Common (1% to 10%): Hypertension
Frequency not reported: Worsening heart failure, QT prolongation and ventricular arrhythmia secondary to hypocalcemia[Ref]

Gastrointestinal

Very common (10% or more): Nausea (31%), vomiting (27%), diarrhea (21%), dyspepsia (13%), abdominal pain (10.9%)
Common (1% to 10%): Upper abdominal pain, dyspepsia, anorexia, constipation[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity reactions
Postmarketing reports: Rash, angioedema, urticaria[Ref]

Local

Common (1% to 10%): Access site infection[Ref]

Dermatologic

Very common (10% or more): Paresthesia (14 to 29%)
Very rare (less than 0.01%): Leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Metabolic

Very common (10% or more): Hypocalcemia (11.2%)
Common (1% to 10%): Hyperkalemia, dehydration[Ref]

Respiratory

Very common (10% or more): Cough (11.7%), upper respiratory infection (11%)
Common (1% to 10%): Dyspnea[Ref]

Endocrine

Common (1% to 10%): Reduced testosterone levels[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (15%), muscle spasms (11%)
Common (1% to 10%): Limb pain, back pain, fracture, arthralgia, noncardiac chest pain[Ref]

Nervous system

Very common (10% or more): Paresthesia (up to 29%), headache (11.5%), dizziness (10%)
Common (1% to 10%): Fatigue, seizures[Ref]

Other

Common (1% to 10%): Asthenia[Ref]

Renal

Common (1% to 10%): Dialysis access site infection[Ref]

References

1. "Product Information. Sensipar (cinacalcet)." Amgen USA, Thousand Oaks, CA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Giannikopoulos G, Zorzou MP, Stamoulis I, et al. "Cinacalcet-induced leukocytoclastic vasculitis." Am J Kidney Dis 54 (2009): e5-e8

4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of cinacalcet may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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