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Calderol Side Effects

Generic Name: calcifediol

Note: This document contains side effect information about calcifediol. Some of the dosage forms listed on this page may not apply to the brand name Calderol.

For the Consumer

Applies to calcifediol: oral capsule extended release, oral capsule liquid filled

Along with its needed effects, calcifediol (the active ingredient contained in Calderol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking calcifediol:

Less common
  • Abdominal or stomach pain
  • chest pain
  • confusion
  • cough
  • cough producing mucus
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • extreme fatigue
  • fever or chills
  • irregular breathing
  • irregular heartbeat
  • muscle pain or stiffness
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain, swelling, or redness in the joints
  • pale skin
  • sneezing
  • sore throat
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
  • weight gain
Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking calcifediol:

Symptoms of overdose
  • Decreased appetite
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • high urine levels of calcium
  • increase in heart rate
  • irritability
  • lightheadedness
  • muscle weakness
  • rapid breathing
  • sunken eyes
  • wrinkled skin

Some side effects of calcifediol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • Bruise
  • muscle aches
  • stuffy or runny nose

For Healthcare Professionals

Applies to calcifediol: oral capsule, oral capsule extended release


Metabolic side effects have included hypercalcemia, and increased phosphate absorption.[Ref]

Early signs and symptoms of hypercalcemia include headache, anorexia, nausea, vomiting, metallic taste, constipation, abdominal cramps, dry mouth, weakness, fatigue, muscle and bone pain, ataxia, tinnitus, and vertigo. Later hypercalcemia may result in pruritus, mental confusion, coma, hypertension, cardiac arrhythmias, seizures, metastatic calcification, and renal insufficiency manifested by polyuria, nocturia, polydipsia, and proteinuria. Patients with renal failure are more prone to the development of hypercalcemia because the urinary excretion of calcium cannot compensate for increases in serum calcium.

Increased phosphate absorption may be detrimental in patients with chronic renal failure and hyperphosphatemia.

Because of the long half-life of calcifediol, reversal of toxic symptoms may take 7 to 30 days.[Ref]


1. "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.

2. "Calcifediol for renal osteodystrophy." Med Lett Drugs Ther 24 (1982): 92-3

3. Araugo OE, Flowers FP, Brown K "Vitamin D therapy in psoriasis." DICP 25 (1991): 835-9

4. Miller SM "New perspectives on vitamin D." Am J Med Technol 49 (1983): 27-37

Some side effects of Calderol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.