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Calderol Side Effects

Generic Name: calcifediol

Note: This page contains information about the side effects of calcifediol. Some of the dosage forms included on this document may not apply to the brand name Calderol.

For the Consumer

Applies to calcifediol: oral capsule extended release, oral capsule liquid filled

In addition to its needed effects, some unwanted effects may be caused by calcifediol (the active ingredient contained in Calderol). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking calcifediol:

Less common:
  • Abdominal or stomach pain
  • chest pain
  • confusion
  • cough
  • cough producing mucus
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • extreme fatigue
  • fever or chills
  • irregular breathing
  • irregular heartbeat
  • muscle pain or stiffness
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain, swelling, or redness in the joints
  • pale skin
  • sneezing
  • sore throat
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
  • weight gain
Incidence not known:
  • Confusion
  • constipation
  • depression
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • loss of appetite
  • metallic taste
  • muscle weakness
  • thirst
  • weight loss

If any of the following symptoms of overdose occur while taking calcifediol, get emergency help immediately:

Symptoms of overdose:
  • Decreased appetite
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • high urine levels of calcium
  • increase in heart rate
  • irritability
  • lightheadedness
  • muscle weakness
  • rapid breathing
  • sunken eyes
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with calcifediol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

  • Bruise
  • muscle aches
  • stuffy or runny nose

For Healthcare Professionals

Applies to calcifediol: oral capsule, oral capsule extended release


Metabolic side effects have included hypercalcemia, and increased phosphate absorption.[Ref]

Early signs and symptoms of hypercalcemia include headache, anorexia, nausea, vomiting, metallic taste, constipation, abdominal cramps, dry mouth, weakness, fatigue, muscle and bone pain, ataxia, tinnitus, and vertigo. Later hypercalcemia may result in pruritus, mental confusion, coma, hypertension, cardiac arrhythmias, seizures, metastatic calcification, and renal insufficiency manifested by polyuria, nocturia, polydipsia, and proteinuria. Patients with renal failure are more prone to the development of hypercalcemia because the urinary excretion of calcium cannot compensate for increases in serum calcium.

Increased phosphate absorption may be detrimental in patients with chronic renal failure and hyperphosphatemia.

Because of the long half-life of calcifediol, reversal of toxic symptoms may take 7 to 30 days.[Ref]


1. "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.

2. "Calcifediol for renal osteodystrophy." Med Lett Drugs Ther 24 (1982): 92-3

3. Araugo OE, Flowers FP, Brown K "Vitamin D therapy in psoriasis." DICP 25 (1991): 835-9

4. Miller SM "New perspectives on vitamin D." Am J Med Technol 49 (1983): 27-37

Not all side effects for Calderol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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