Calcijex Side Effects
Generic Name: calcitriol
Note: This page contains information about the side effects of calcitriol. Some of the dosage forms included on this document may not apply to the brand name Calcijex.
For the Consumer
Applies to calcitriol: capsules, oral solution
When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur while taking calcitriol (the active ingredient contained in Calcijex)
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; bone pain; constipation; decreased sex drive; diarrhea; difficult or painful urination; dizziness; drowsiness; dry mouth; eye redness or irritation; fever; flushing; frequent urination; headache; increased body temperature; increased thirst; irregular heartbeat; loss of appetite; mental or mood changes; metallic taste; muscle pain; nausea; runny nose; sensitivity of the eyes to sunlight; stomach pain or cramps; unexplained weight loss; unusual thinking; vomiting; weakness.
For Healthcare Professionals
Applies to calcitriol: injectable solution, oral capsule, oral liquid
Early signs and symptoms of hypercalcemia include headache, anorexia, nausea, vomiting, metallic taste, constipation, abdominal cramps, dry mouth, weakness, fatigue, muscle and bone pain, ataxia, tinnitus, abdominal pain, and vertigo. Later hypercalcemia may result in pruritus, mental confusion, coma, elevated hepatic transaminase levels, hypertension, cardiac arrhythmias, seizures, metastatic calcification, and renal insufficiency manifested by polyuria, nocturia, polydipsia, and proteinuria and elevated BUN.
In one study, the incidence of hypercalcemia was lower (50% vs 80%) when calcitriol (the active ingredient contained in Calcijex) was administered at night as opposed to morning administration. Hypercalcemia also appears to occur more commonly in patients receiving intermittent vs. continuous therapy and in oral vs. intravenous therapy.
Patients with renal failure are more prone to the development of hypercalcemia because the urinary excretion of calcium cannot compensate for increases in serum calcium.
Increased phosphate absorption may be detrimental in patients with chronic renal failure and hyperphosphatemia.[Ref]
Metabolic side effects have included hypercalcemia and increased phosphate absorption.[Ref]
Hypersensitivity side effects have included rare cases of hypersensitivity reactions, including anaphylaxis. A single case of erythema multiform has been reported. Another case involving a single patient experiencing an allergic reaction including total body hives and swelling of the lips has also been reported.[Ref]
1. Maxwell DR, Benjamin DM, Donahay SL, Allen MK, Hamburger RJ, Luft FC "Calcitriol in dialysis patients." Clin Pharmacol Ther 23 (1978): 515-9
2. Tsukamoto Y, Mariyo R, Nomura Y, Sato N, Faugere MC, Malluche HH "Long-term effect of oral calcitriol pulse therapy on bone in hemodialysis patients." Bone 14 (1993): 421-5
3. Miller SM "New perspectives on vitamin D." Am J Med Technol 49 (1983): 27-37
4. "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
5. Coburn JW "Use of oral and parenteral calcitriol in the treatment of renal osteodystrophy." Kidney Int Suppl 29 (1990): s54-61
6. Malluche HH, Faugere MC "Effects of 1,25(OH)2D3 administration on bone in patients with renal failure." Kidney Int Suppl 29 (1990): s48-53
7. Araugo OE, Flowers FP, Brown K "Vitamin D therapy in psoriasis." DICP 25 (1991): 835-9
8. Schaefer K, Umlauf E, von Herrath D "Reduced risk of hypercalcemia for hemodialysis patients by administering calcitriol at night." Am J Kidney Dis 19 (1992): 460-4
9. Arik N, Basoglu T, Sungur C, Adam B, Bedir A, Kandemir T, Coskun C, Bernay I "Hyperphosphatemia: A serious limiting factor preventing the possible benefit from intravenous calcitriol therapy." Nephron 82 (1999): 77-8
10. Mazess RB, Elangovan L "A review of intravenous versus oral vitamin D hormone therapy in hemodialysis patients." Clin Nephrol 59 (2003): 319-25
11. Herrmann P, Ritz E, Schmidt-Gayk H, Schafer I, Geyer J, Nonnast-Daniel B, Koch KM, Weber U, Horl W, Haas-Worle A, et al "Comparison of intermittent and continuous oral administration of calcitriol in dialysis patients: a randomized prospective trial." Nephron 67 (1994): 48-53
Not all side effects for Calcijex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about Calcijex (calcitriol)
- Other brands: Rocaltrol
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