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Calcijex Side Effects

Generic Name: calcitriol

Note: This page contains information about the side effects of calcitriol. Some of the dosage forms included on this document may not apply to the brand name Calcijex.

For the Consumer

Applies to calcitriol: oral capsules, oral solution, parenteral injection

Side effects include:

Excessive vitamin D intake (early manifestations): weakness, headache, somnolence, nausea, dry mouth, constipation, muscle or bone pain, metallic taste.

Excessive vitamin D intake (late manifestations): polyuria, polydipsia, anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated AST, elevated ALT, ectopic calcification, nephrocalcinosis, hypertension, cardiac arrhythmias, dystrophy, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections.

For Healthcare Professionals

Applies to calcitriol: injectable solution, oral capsule, oral liquid

General

Early signs of excessive vitamin D intake include weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, anorexia, abdominal pain, or stomach ache. Late signs include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated AST and ALT, ectopic calcification, nephrocalcinosis, hypertension, cardiac arrhythmias, dystrophy, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and rarely, overt psychosis.[Ref]

Adverse events were similar to those of excessive vitamin D intake, hypercalcemia syndrome or calcium intoxication.[Ref]

Metabolic

Very common (10% or more): Hypercalcemia
Uncommon (0.1% to 1%): Decreased appetite
Frequency not reported: Polydipsia, dehydration, weight loss, thirst, hyperphosphatemia, anorexia, hypercholesterolemia[Ref]

Genitourinary

Common (1% to 10%): Hypercalciuria, urinary tract infection
Frequency not reported: Polyuria, nocturia, albuminuria[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Sensory disturbance, somnolence, metallic taste
Postmarketing reports: Seizure[Ref]

Hypersensitivity

Frequency not reported: Allergic reaction, hypersensitivity (including rash, erythema, pruritus, and urticaria)
Postmarketing reports: Anaphylaxis[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Vomiting
Frequency not reported: Constipation, abdominal pain upper, paralytic ileus, dry mouth, pancreatitis, epigastric discomfort, diarrhea[Ref]

Dermatologic

Common (1% to 10%): Rash
Frequency not reported: Urticaria, erythema, pruritus, erythema multiforme[Ref]

Cardiovascular

Frequency not reported: Cardiac arrhythmias, cardiac arrest, hypertension[Ref]

Hepatic

Frequency not reported: Elevated AST, elevated ALT[Ref]

Other

Frequency not reported: Calcinosis, pyrexia, weakness, hyperthermia, ectopic calcification, dystrophy
Postmarketing reports: Chest pain[Ref]

Renal

Uncommon (0.1% to 1%): Blood creatinine increased
Frequency not reported: Elevated BUN, nephrocalcinosis, impairment of renal function[Ref]

Musculoskeletal

Frequency not reported: Muscular weakness, growth retardation, muscle pain, bone pain[Ref]

Psychiatric

Frequency not reported: Apathy, psychiatric disturbances, decreased libido, overt psychosis[Ref]

Local

Frequency not reported: Pain on injection
Postmarketing reports: Bleeding at the venipuncture site[Ref]

Hematologic

Postmarketing reports: Hemolysis[Ref]

Oncologic

Postmarketing reports: Brown tumor, non-malignant tumor on the ribs[Ref]

Ocular

Frequency not reported: Conjunctivitis (calcific), photophobia[Ref]

Respiratory

Frequency not reported: Rhinorrhea[Ref]

References

1. "Product Information. Calcijex (calcitriol)." Abbott Pharmaceutical, Abbott Park, IL.

2. "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for Calcijex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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