Skip to main content

Boostrix (Tdap) Side Effects

Generic name: diphtheria toxoid / pertussis, acellular / tetanus toxoid

Medically reviewed by Drugs.com. Last updated on Jan 23, 2025.

Note: This document provides detailed information about Boostrix (Tdap) Side Effects associated with diphtheria toxoid / pertussis, acellular / tetanus toxoid. Some dosage forms listed on this page may not apply specifically to the brand name Boostrix (Tdap).

Applies to diphtheria toxoid / pertussis, acellular / tetanus toxoid: intramuscular suspension.

Precautions

It is very important that you call the doctor right away if you or your child have any unwanted effects after receiving the vaccine. This may include fainting, seizures, a high fever, crying that will not stop, or severe redness or swelling where the shot was given.

This vaccine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, swelling of the tongue and throat, or trouble breathing after you get the injection.

Fainting may occur after you receive this vaccine. You may also have vision changes, numbness or tingling in your arms, hands, or feet, or jerky movements of the arms and legs. Call the doctor right away if you or your child have any of these symptoms.

It is very important to tell the doctor if you or your child are allergic to rubber. The tip caps of the prefilled syringes may contain dry natural latex rubber. This may cause an allergic reaction if you have a latex allergy.

This vaccine will not treat an active infection. If you or your child have a diphtheria, tetanus, or pertussis infection, you will need medicine to treat the infection.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Boostrix (Tdap)

Some side effects of diphtheria toxoid / pertussis, acellular / tetanus toxoid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • body aches
  • diarrhea
  • fever of 99.5 degrees F or more
  • redness, swelling, tenderness, pain, or a lump at the injection of site
  • tiredness

Incidence not known

Serious side effects of Boostrix (Tdap)

Along with its needed effects, diphtheria toxoid/pertussis, acellular/tetanus toxoid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking diphtheria toxoid / pertussis, acellular / tetanus toxoid:

Less common side effects

  • crying for 3 or more hours
  • fainting

Rare side effects

  • blurred vision
  • confusion
  • difficulty with breathing or swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever of 102.2 degrees F or more
  • headache (severe or continuing)
  • hives or welts
  • itching, especially of the feet or hands
  • reddening of the skin, especially around the ears
  • seizures
  • sleepiness (unusual and continuing)
  • sweating
  • swelling of the eyes, face, or inside of the nose
  • unusual tiredness or weakness (sudden and severe)
  • vomiting (severe or continuing)

Incidence not known

  • blood in the urine
  • bloody or black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain, discomfort, or tightness
  • chills
  • cough
  • dizziness
  • dry mouth
  • fast heartbeat
  • flushed, dry skin
  • fruit-like breath odor
  • inability to move the arms and legs
  • increased hunger
  • increased thirst
  • increased urination
  • large, flat, blue or purplish patches on the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss of consciousness
  • muscle pain or spasms
  • nausea
  • painful knees and ankles
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness and swelling on the skin, buttocks, legs, or ankles
  • skin rash
  • stiff neck
  • stomach pain
  • sudden numbness and weakness in the arms and legs
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • unexplained weight loss

For healthcare professionals

Applies to diphtheria toxoid / pertussis, acellular / tetanus toxoid: intramuscular suspension.

General adverse events

The most reported side effects included injection site pain, injection site erythema, and injection site swelling.[Ref]

Cardiovascular

Dermatologic

Gastrointestinal

Hematologic

Hypersensitivity

Local

Metabolic

Musculoskeletal

Nervous system

Other

See also:

References

1. "Product Information. Adacel (Tdap) (tetanus/diphtheria/pertussis (Tdap) adult/adolescent vaccine)." Aventis Pharmaceuticals

2. Cerner Multum, Inc. "Australian Product Information."

3. (2024) "Product Information. Adacel (diphtheria/tetanus/pertussis (dTpa))." Sanofi

Frequently asked questions

Further information

Boostrix (Tdap) side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.