Boostrix (Tdap) Side Effects

Generic name: diphtheria toxoid / pertussis, acellular / tetanus toxoid

Medically reviewed by Drugs.com. Last updated on Nov 23, 2024.

Note: This document provides detailed information about Boostrix (Tdap) Side Effects associated with diphtheria toxoid / pertussis, acellular / tetanus toxoid. Some dosage forms listed on this page may not apply specifically to the brand name Boostrix (Tdap).

Applies to diphtheria toxoid / pertussis, acellular / tetanus toxoid: intramuscular suspension.

Common side effects of Boostrix (Tdap)

Some side effects of diphtheria toxoid / pertussis, acellular / tetanus toxoid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• body aches
• diarrhea
• fever of 99.5 degrees F or more
• headache
• redness, swelling, tenderness, pain, or a lump at the place of injection
• tiredness

Incidence not known

• back pain
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• injection site bruising
• muscle or joint pain
• swollen, painful, or tender lymph glands in the neck, armpit, or groin
• weakness of the muscles in the face
• welts on the skin

Serious side effects of Boostrix (Tdap)

Along with its needed effects, diphtheria toxoid/pertussis, acellular/tetanus toxoid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking diphtheria toxoid / pertussis, acellular / tetanus toxoid:

Less common side effects

• crying for 3 or more hours
• fainting

Rare side effects

• confusion
• convulsions (seizures)
• difficulty with breathing or swallowing
• fever of 102.2 degrees F or more
• headache (severe or continuing)
• hives
• itching, especially of the feet or hands
• low blood pressure
• reddening of the skin, especially around the ears
• sleepiness (unusual and continuing)
• swelling of the eyes, face, or inside of the nose
• unusual tiredness or weakness (sudden and severe)
• vomiting (severe or continuing)

Incidence not known

• blood in the urine
• bloody or black, tarry stools
• blurred vision
• chest pain or discomfort
• chills
• cough
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fast heartbeat
• flushed, dry skin
• fruit-like breath odor
• inability to move the arms and legs
• increased hunger
• increased thirst
• increased urination
• large, flat, blue, or purplish patches on the skin
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of consciousness
• muscle pain or spasm
• nausea
• painful knees and ankles
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness and swelling on the skin, buttocks, legs, or ankles
• shortness of breath
• skin rash
• stiff neck
• stomach pain
• sudden numbness and weakness in the arms and legs
• sweating
• tightness in the chest
• trouble breathing
• unexplained weight loss
• unusual tiredness or weakness
• wheezing

For healthcare professionals

Applies to diphtheria toxoid / pertussis, acellular / tetanus toxoid: intramuscular suspension.

General adverse events

The most reported side effects included injection site pain, injection site erythema, and injection site swelling.^[Ref]

Cardiovascular

• Frequency not reported: Hypotension, edema, myocarditis^[Ref]

Dermatologic

• Common (1% to 10%): Rash
• Frequency not reported: Angioedema, pruritus, urticaria^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (13.3%), diarrhea (10.3%)
• Common (1% to 10%): Vomiting^[Ref]

Hematologic

• Common (1% to 10%): Lymph node swelling/axillary adenopathy^[Ref]

Hypersensitivity

• Frequency not reported: Anaphylactic reaction, hypersensitivity reaction,
• Postmarketing reports: Arthus hypersensitivity^[Ref]

Local

• Very common (10% or more): Injection site pain (87.1%), injection site erythema (24.7%), injection site swelling (21%)
• Frequency not reported: Injection site bruising, injection site nodule, injection site sterile abscess
• Postmarketing reports: Large (over 50 mm) injection site reactions, extensive limb swelling from the injection site beyond one or both joints^[Ref]

Metabolic

• Very common (10% or more): Anorexia/decreased appetite^[Ref]

Musculoskeletal

• Very common (10% or more): Body ache or muscle weakness (30.4%), chills (15.1%), sore and swollen joints (11.3%), arthralgia
• Common (1% to 10%): Myalgia
• Frequency not reported: Myositis
• Postmarketing reports: Muscle spasm^[Ref]

Nervous system

• Very common (10% or more): Headache (43.7%)
• Frequency not reported: Brachial neuritis, convulsions, facial palsy, Guillain-Barre syndrome, hypoesthesia, myelitis, nerve compression in neck and left arm, paresthesia, severe migraine with unilateral facial paralysis, syncope^[Ref]

Other

• Very common (10% or more): Tiredness/fatigue/asthenia (31.5%), chills (15.1%), malaise
• Common (1% to 10%): Fever/pyrexia^[Ref]

Frequently asked questions

• DTaP vs Tdap Vaccines - What's the difference between them?

Further information

Boostrix (Tdap) side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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