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Binimetinib Side Effects

Medically reviewed by Last updated on Apr 24, 2022.

For the Consumer

Applies to binimetinib: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, binimetinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking binimetinib:

More common

  • Bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision or any other change in vision
  • chest pain
  • coughing up blood
  • decreased urine output
  • difficulty in breathing or swallowing
  • dilated neck veins
  • dizziness
  • extreme tiredness or weakness
  • fever
  • headache
  • hoarseness
  • increased menstrual flow or vaginal bleeding
  • irregular breathing
  • irregular heartbeat
  • irritation
  • itching, hives, skin rash
  • joint pain, stiffness, or swelling
  • nervousness
  • nosebleed
  • paralysis
  • pounding in the ears
  • prolonged bleeding from cuts
  • rapid weight gain
  • red or black, tarry stools
  • red or dark brown urine
  • redness of the skin
  • slow or fast heartbeat
  • stomach cramps
  • tenderness
  • tightness in the chest
  • tingling of the hands or feet
  • trouble seeing
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • watery or bloody diarrhea

Side effects not requiring immediate medical attention

Some side effects of binimetinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to binimetinib: oral tablet


Very common (10% or more): Anemia (36%), hemorrhage (19%), leukopenia (13%), lymphoma (13%), neutropenia (13%)

Common (1% to 10%): Venous thromboembolism (VTE)[Ref]


Common (1% to 10%): Hypersensitivity[Ref]


Uncommon (0.1% to 1%): Rhabdomyolysis[Ref]


Very common (10% or more): Retinopathy (20%), visual impairment (20%)

Common (1% to 10%): Retinal detachment, macular edema, uveitis

Uncommon (0.1% to 1%): Retinal vein occlusion[Ref]


Very common (10% or more): Hyponatremia (18%), peripheral edema (13%)[Ref]


Very common (10% or more): Increased gamma glutamyl transferase (45%)

Common (1% to 10%): Alanine aminotransferase (ALT) increased, aspartate aminotransferase (AST) increased

Uncommon (0.1% to 1%): Alkaline phosphatase increased[Ref]


Uncommon (0.1% to 1%): Interstitial lung disease[Ref]


Very common (10% or more): Fatigue (43%), pyrexia (18%)[Ref]

Nervous system

Very common (10% or more): Dizziness (15%)[Ref]


Very common (10% or more): Increased creatinine (93%), increased creatine phosphokinase (58%)[Ref]


Very common (10% or more): Hypertension (11%)

Common (1% to 10%): Cardiomyopathy, fatal intracranial hemorrhage (in the setting of new or progressive brain metastases)[Ref]


Very common (10% or more): Rash (22%)

Common (1% to 10%): Panniculitis[Ref]


Very common (10% or more): Nausea (41%), diarrhea (36%), vomiting (30%), abdominal pain (28%), constipation (22%)

Common (1% to 10%): Rectal hemorrhage, hematochezia, hemorrhoidal hemorrhage, colitis[Ref]

Frequently asked questions


1. "Product Information. Mektovi (binimetinib)." Array BioPharma Inc. (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.