Betrixaban Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 8, 2023.

Applies to betrixaban: oral capsule.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be signs of bleeding problems.

Be extra careful to avoid injuries. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Gently brush and floss your teeth. Be careful when using sharp objects, including razors and fingernail clippers.

This medicine may increase the risk of blood clots in the spine or epidural area, which may lead to long-term or permanent paralysis. This is more likely to occur if you have an epidural catheter placed in your back, are taking NSAID or blood clotting medicine, a history of repeated epidural punctures or problems with your spine, or have had surgery on your spine. Tell your doctor right away if you have tingling, numbness, or muscle weakness, especially in your legs and feet.

Make sure any doctor who treats you knows that you are using this medicine. You may need to stop using this medicine for several days before having surgery, including dental procedures.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Serious side effects of betrixaban

Along with its needed effects, betrixaban may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betrixaban:

Other side effects of betrixaban

Some side effects of betrixaban may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to betrixaban: oral capsule.

General adverse events

The most common adverse events were related to bleeding.^[Ref]

Hematologic

• Common (1% to 10%): Clinically relevant non-major bleeding
• Uncommon (0.1% to 1%): Major bleeding (gastrointestinal, intracranial, and fatal)

Cardiovascular

• Common (1% to 10%): Hypertension^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, nausea, diarrhea^[Ref]

Respiratory

• Common (1% to 10%): Epistaxis^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

Hypersensitivity

• Rare (less than 0.1%): Moderate hypersensitivity^[Ref]

See also:

Further information

Betrixaban side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer