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APL Side Effects

Generic name: chorionic gonadotropin (hcg)

Medically reviewed by Last updated on Apr 18, 2024.

Note: This document contains side effect information about chorionic gonadotropin (hcg). Some dosage forms listed on this page may not apply to the brand name APL.

Applies to chorionic gonadotropin (hcg): powder for solution, solution.

Serious side effects of APL

Along with its needed effects, chorionic gonadotropin (hcg) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking chorionic gonadotropin (hcg):

For females only

More common

Less common or rare

For boys only

Less common

Incidence not known

Other side effects of APL

Some side effects of chorionic gonadotropin (hcg) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to chorionic gonadotropin (hcg): injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection, subcutaneous solution.


HCG: The most commonly reported side effects included rash, groin pain, loin pain, and fever.

r-HCG: The most commonly reported side effects included injection site pain, headache not otherwise specified (NOS), nausea, and application site disorders.[Ref]



Frequency not reported: injection site pain, injection site rash, localized hypersensitivity reaction


Very common (10% or more): Injection site pain (up to 19.5%), application site disorder (up to 14.6%)

Common (1% to 10%): Injection site bruising, injection site inflammation, injection site reaction, vessel site hemorrhage[Ref]

Nervous system


Frequency not reported: Headache


Very common (10% or more): Headache NOS (up to 18%)

Common (1% to 10%): Headache

Frequency not reported: Dizziness, hypesthesia, paresthesia, twitching[Ref]



Rare (0.01% to 0.1%: Fever

Frequency not reported: Fatigue, pain, swelling, tiredness


Very common (10% or more): Post-operative pain (up to 15.7%)

Common (1% to 10%): Pain, pyrexia, rigors, tiredness

Frequency not reported: Body pain, chromosomal abnormality (47, XXX), congenital anomaly of the fetus/newborn, Down's syndrome, fever, major congenital malformations, malaise, missed abortion, placenta previa, premature birth, premature labor, spontaneous abortion[Ref]



Frequency not reported: Abdominal discomfort, abdominal pain, acute abdominal pain, ascites, bloating, diarrhea, gastrointestinal symptoms, nausea


Very common (10% or more): Nausea (up to 14.6%), abdominal pain (up to 11.2%)

Common (1% to 10%): Abdominal pain lower, mouth ulceration, vomiting

Uncommon (0.1% to 1%): Diarrhea

Frequency not reported: Abdominal enlargement, flatulence, hemoperitoneum[Ref]



Frequency not reported: Large ovarian cysts (prone to rupture), mild ovarian hyperstimulation syndrome (OHSS), mild to moderate enlargement of ovaries, ovarian cysts, painful breasts, severe OHSS, unwanted ovarian hyperstimulation


Common (1% to 10%): Dysmenorrhea, intermenstrual bleeding, ovarian cyst, ovarian hyperstimulation, mild/moderate OHSS

Uncommon (0.1% to 1%): Breast pain, severe OHSS

Frequency not reported: Adnexal torsion, albuminuria, cervical lesion, dysuria, ectopic pregnancy, genital herpes, genital moniliasis, leukorrhea, mild to moderate ovarian enlargement, ovarian enlargement, ovarian torsion, postpartum fever, urinary incontinence, urinary tract infection, uterine disorders, vaginal discomfort, vaginal hemorrhage, vaginitis[Ref]



Frequency not reported: Dyspnea, hydrothorax, shortness of breath


Common (1% to 10%): Pharyngolaryngeal pain, rhinorrhea, upper respiratory tract infections NOS

Frequency not reported: Acute pulmonary distress, cough, hiccup, pharyngitis, pulmonary complications, upper respiratory tract infection[Ref]



Common (1% to 10%): Rash

Rare (0.01% to 0.1%): Generalized rash

Frequency not reported: Acne, erythema/redness, itching, urticaria


Common (1% to 10%): Ecchymosis

Very rare (less than 0.01%): Mild reversible skin reactions, rash

Frequency not reported: Pruritus[Ref]



Common (1% to 10%): Groin pain, loin pain

Frequency not reported: Back pain, cranial malformation[Ref]



Frequency not reported: Depression, irritability, mood changes, restlessness


Common (1% to 10%): Emotional disturbance NOS

Uncommon (0.1% to 1%): Depression, irritability, restlessness

Frequency not reported: Emotional lability, insomnia[Ref]


Human Chorionic Gonadotropin (HCG):

Frequency not reported: Bruising, edema, thromboembolism

Recombinant Chorionic Gonadotropin (r-HCG):

Common (1% to 10%): Peripheral swelling

Very rare (less than 0.01%): Shock, thromboembolism

Frequency not reported: Atrial septal defect, cardiac arrhythmia, heart murmur, hot flashes, vascular complications

Postmarketing reports: Thromboembolic events[Ref]



Common (1% to 10%): Pyelonephritis NOS[Ref]



Frequency not reported: Allergic reactions, angioedema, systemic hypersensitivity reactions


Very rare (less than 0.01%): Anaphylactic reactions, mild to severe hypersensitivity reactions

Postmarketing reports: Allergic reactions, mild systemic allergic reactions[Ref]



Frequency not reported: Sodium retention, water retention, weight gain


Frequency not reported: Hyperglycemia[Ref]



Frequency not reported: Excessive androgen production, gynecomastia, precocious puberty[Ref]



Frequency not reported: Benign/malignant ovarian neoplasms, cervical carcinoma[Ref]



Frequency not reported: Leukocytosis[Ref]


1. "Product Information. Pregnyl (chorionic gonadotropin (HCG))." Organon

2. (2022) "Product Information. Novarel (chorionic gonadotropin (HCG))." Ferring Pharmaceuticals Inc

3. "Product Information. Ovidrel (chorionic gonadotropin (HCG))." Serono Laboratories Inc

4. Cerner Multum, Inc. "UK Summary of Product Characteristics."

5. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.