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Anavip Side Effects

Generic Name: antivenin (crotalidae) polyvalent

Note: This document contains side effect information about antivenin (crotalidae) polyvalent. Some of the dosage forms listed on this page may not apply to the brand name Anavip.

For the Consumer

Applies to antivenin (crotalidae) polyvalent: injection kit

Other dosage forms:

Along with its needed effects, antivenin (crotalidae) polyvalent (the active ingredient contained in Anavip) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking antivenin (crotalidae) polyvalent:

More Common

  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

For up to 24 days after you have received pit viper antivenin, you may develop symptoms of a side effect called serum sickness. The severity of the symptoms and the length of the sickness depend on the amount of pit viper antivenin you were given and how long the treatment lasted. During the 24 days after treatment with pit viper antivenin, check with your doctor if you notice any of the following side effects:

  • Fever
  • joint pain
  • rash and itching
  • swollen lymph glands

For Healthcare Professionals

Applies to antivenin (crotalidae) polyvalent: injectable solution, intravenous powder for injection

General

The most common adverse events were urticaria and rash.

Dermatologic

Very common (10% or more): Urticaria (16%), rash (11%)

Common (1% to 10%): Pruritus, cellulitis, subcutaneous nodule, ecchymosis

Postmarketing reports: Erythema, hyperhidrosis, angioedema

Hypersensitivity

Allergic reaction consisted of urticaria, dyspnea, and wheezing. Serum sickness included urticaria, cough, rash, pruritus, and urticaria. Acute allergic reactions manifested as anxiety, bronchospasm, chills, edema, fever, hypotension, pruritus, rash, urticaria, voice alteration, and/or wheezing.[Ref]

Common (1% to 10%): Allergic reaction, serum sickness

Postmarketing reports: Acute allergic reactions including anaphylaxis or anaphylactoid reactions, delayed allergic reaction.[Ref]

Hematologic

Common (1% to 10%): Coagulation disorder

Postmarketing reports: Delayed or recurrent coagulopathy or thrombocytopenia, thrombocytopenia refractory to treatment, bleeding

Cardiovascular

Common (1% to 10%): Hypotension

Postmarketing reports: Tachycardia

Nervous system

Common (1% to 10%): General paresthesia, nervousness

Postmarketing reports: Tremor, dizziness, headache[Ref]

Respiratory

Common (1% to 10%): Asthma, cough, increased sputum

Postmarketing reports: Tachypnea, bronchospasm, wheezing, tracheal edema, dyspnea

Musculoskeletal

Common (1% to 10%): Back pain, myalgia

Postmarketing reports: Musculoskeletal chest pain, chills

Gastrointestinal

Common (1% to 10%): Nausea, anorexia, circumoral paresthesia

Postmarketing reports: Tongue swelling, lip swelling

Other

Common (1% to 10%): Chest pain, wound infection, chills

Postmarketing reports: Failure to achieve initial control, recurrent swelling refractory to treatment, prolonged hospitalization, treatment failure resulting in death, chest discomfort, swelling

Psychiatric

Common (1% to 10%): Nervousness

Ocular

Postmarketing reports: Worsening eye sight

References

1. "Product Information. Crofab (antivenin (crotalidae) polyvalent)" Savage Laboratories, Melville, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Anavip (antivenin (crotalidae) polyvalent)

Consumer resources

Other brands: CroFab, Antivenin Polyvalent

Professional resources

Related treatment guides

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