Alka-Seltzer Plus Day & Night Cold Formula (Night Cold) Side Effects

Generic name: aspirin / dextromethorphan / doxylamine / phenylephrine

Note: This document contains side effect information about aspirin / dextromethorphan / doxylamine / phenylephrine. Some dosage forms listed on this page may not apply to the brand name Alka-Seltzer Plus Day & Night Cold Formula (Night Cold).

Applies to aspirin / dextromethorphan / doxylamine / phenylephrine: oral tablet effervescent.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe sore throat that lasts for more than 2 days, or followed by fever, headache, rash, nausea, or vomiting.

Stop using this medicine and call your doctor at once if you have:

stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
stomach pain that does not go away;
pain, cough, or nasal congestion that gets worse or lasts more than 7 days;
fever that gets worse or lasts more than 3 days;
redness or swelling;
ringing in the ears or hearing loss;
cough returns or occurs with rash or headache; or
nervousness, dizziness, or sleep problems.