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Abemaciclib Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 24, 2023.

Applies to abemaciclib: oral tablet.

Serious side effects of Abemaciclib

Along with its needed effects, abemaciclib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking abemaciclib:

More common

Less common


Other side effects of Abemaciclib

Some side effects of abemaciclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to abemaciclib: oral tablet.


The most common adverse reactions reported (20% or greater incidence) were increased creatinine (98%), decreased white blood cell count (91%), diarrhea (90%), decreased neutrophil count (88%), anemia (84%), fatigue/asthenia (65%), nausea (64%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), decreased appetite (45%), infections (43%), increased ALT (41%), abdominal pain (39%), increased AST (37%), vomiting (35%), leukopenia (28%), and thrombocytopenia (20%).[Ref]


Common (1% to 10%): Venous thromboembolic events[Ref]


Very common (10% or more): Alopecia (21%), pruritus (14%), rash (13%)[Ref]


Very common (10% or more): Diarrhea (85%), nausea (64%), abdominal pain (39%), vomiting (28%), constipation (17%), stomatitis (15%), dry mouth (14%)[Ref]


Very common (10% or more): Decreased white blood cell count (91%), decreased neutrophil count (88%), anemia (84%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), leukopenia (28%), thrombocytopenia (20%)

Common (1% to 10%): Febrile neutropenia, lymphopenia

Frequency not reported: Neutropenic sepsis[Ref]


Very common (10% or more): Increased ALT (41%), increased AST (37%)[Ref]


Very common (10% or more): Decreased appetite (27%), decreased weight (14%), dehydration (10%)[Ref]


Very common (10% or more): Arthralgia (15%)[Ref]

Nervous system

Very common (10% or more): Headache (20%), dysgeusia (14%), dizziness (13%)


Very common (10% or more): Fatigue/asthenia (65%), infections (43%), peripheral edema (12%), pyrexia (11%)[Ref]


Very common (10% or more): Increased creatinine (98%)[Ref]


Very common (10% or more): Cough (19%)

Common (1% to 10%): Interstitial lung disease, pneumonitis[Ref]

Frequently asked questions


1. Product Information. Verzenio (abemaciclib). Lilly, Eli and Company. 2023.

2. Product Information. Verzenio (abemaciclib). Eli Lilly Australia Pty Ltd. 2023.

3. Product Information. Verzenios (abemaciclib). Eli Lilly and Company Ltd. 2023.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.