Generic Name: maraviroc (ma RAV i rok)
Brand Names: Selzentry
Medically reviewed on December 3, 2017
What is Selzentry?
Selzentry (maraviroc) is an antiviral medicine that prevents certain viral cells from multiplying in your body.
Selzentry is used with other medications to treat CCR5-tropic human immunodeficiency virus (HIV) type 1. HIV causes the acquired immunodeficiency syndrome (AIDS).
Selzentry is for use in adults and children who are at least 2 years old. Maraviroc is not a cure for HIV or AIDS.
If you have severe kidney disease, you may not be able to take Selzentry if you use certain other medications. Tell your doctor about all other medications you use.
Selzentry may cause serious liver problems. Stop taking this medicine and call your doctor at once if you have: itching or rash, vomiting, upper stomach pain, dark urine, or jaundice (yellowing of the skin or eyes).
Before taking this medicine
You should not use Selzentry if you are allergic to maraviroc.
If you have severe or end-stage kidney disease, you may not be able to take Selzentry if you use certain medications, including some antibiotics or antifungal medications, some heart or blood pressure medicines, St. John's wort, and certain drugs to treat hepatitis or tuberculosis. Tell your doctor about all other medications you use.
To make sure this medicine is safe for you, tell your doctor if you have:
kidney disease (or if you are on dialysis);
liver disease, especially hepatitis B or C;
low blood pressure; or
a history of stroke or circulation problems.
HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. Tell your doctor if you become pregnant during treatment.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Selzentry on the baby.
Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Selzentry should not be given to a child who is under 2 years old or who weighs less than 22 pounds (10 kilograms).
How should I take Selzentry?
Take Selzentry exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Before you are treated with Selzentry, your doctor may perform a blood test to make sure this medicine is the right treatment for your type of HIV.
Selzentry must be given in combination with other antiviral medications and it should not be used alone.
You may take this medicine with or without food.
Do not crush, chew, or break the Selzentry tablet. Swallow the tablet whole.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
If a child is using this medicine, tell your doctor if the child has any changes in weight. Maraviroc doses are based on weight in children, and any changes may affect your child's dose.
Use Selzentry regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.
Store at room temperature away from moisture and heat.
Selzentry dosing information
Usual Adult Dose for HIV Infection:
With potent CYP450 3A inhibitors (with or without a potent CYP450 3A inducer) including protease inhibitors (except tipranavir/ritonavir), delavirdine, ketoconazole, itraconazole, clarithromycin, other potent CYP450 3A inhibitors (e.g., nefazodone, telithromycin), boceprevir, telaprevir: 150 mg orally twice a day
With other concomitant medications, including tipranavir/ritonavir, nevirapine, raltegravir, all NRTIs, enfuvirtide: 300 mg orally twice a day
With potent CYP450 3A inducers (without a potent CYP450 3A inhibitor) including efavirenz, rifampin, etravirine, carbamazepine, phenobarbital, phenytoin: 600 mg orally twice a day
Use: In combination with other antiretroviral agents, for patients infected with only CCR5-tropic HIV-1
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Selzentry?
Avoid taking an herbal supplement containing St. John's wort at the same time you are taking Selzentry.
Selzentry may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Taking this medicine will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Selzentry side effects
Get emergency medical help if you have signs of an allergic reaction to Selzentry: hives, difficult breathing, swelling in your face or throat, or a severe skin reaction: fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Selzentry.
Call your doctor at once if you have a side effect such as:
a light-headed feeling, like you might pass out;
chest pressure, tight feeling in your neck or jaw, sweating, pain spreading to your arm or shoulder; or
liver problems - loss of appetite, upper stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
Selzentry may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment. Tell your doctor if you have:
Mb>signs of a new infection - fever, night sweats, swollen glands, diarrhea, stomach pain, weight loss;
chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;
cold sores, sores on your genital or anal area;
rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;
trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or
swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.
Common Selzentry side effects may include:
fever, cold symptoms, cough;
indigestion, gas, bloating, nausea, vomiting, diarrhea, constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Selzentry?
Many drugs can interact with maraviroc. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Selzentry, especially:
all of your HIV/AIDS medications;
an antibiotic - clarithromycin, telithromycin;
antifungal medicine - itraconazole, ketoconazole, posaconazole, voriconazole;
heart medication - nicardipine, quinidine;
hepatitis C medicine - boceprevir or telaprevir;
seizure medicine - carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
tuberculosis medicine - isoniazid, rifabutin, rifampin, rifapentine.
This list is not complete and many other drugs can interact with maraviroc. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Selzentry only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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