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Sacituzumab govitecan

Pronunciation: SAK-i-TOOZ-ue-mab-GOE-vi-TEE-kan
Generic name: sacituzumab govitecan-hziy
Brand name: Trodelvy
Dosage form: injection for intravenous infusion
Drug class: Miscellaneous antineoplastics

Medically reviewed by Carmen Pope, BPharm. Last updated on May 10, 2024.

What is Sacituzumab govitecan (Trodelvy)?

Sacituzumab govitecan (full biologic name sacituzumab govitecan-hziy) is a targeted antibody-drug conjugate (ADC) that may be used to treat adults with the following cancers that have spread (metastasized) or cannot be removed by surgery:

Sacituzumab govitecan is an ADC that is designed to deliver anticancer medicine directly into cells with Trop-2 proteins. Research has found certain types of cancer cells contain more Trop-2 protein than noncancerous cells.

Sacituzumab govitecan (sacituzumab govitecan-hziy) contains 3 different substances:

Sacituzumab govitecan works by binding to Trop-2-expressing cancer cells. It is then taken up by the cell and the linker is hydrolyzed (broken apart) releasing SN-38 directly into the cell. SN-38 interacts with the enzyme topoisomerase I, causing single-strand breaks and DNA damage, leading to cell death and decreased tumor growth.

For metastatic HR+/HER2- breast cancer in men and women who had previously received endocrine-based therapy and at least two additional systemic therapies in the metastatic setting, sacituzumab govitecan is now recommended by the National Comprehensive Cancer Network (NCCN) as Category 1 or preferred treatment.

Sacituzumab govitecan was first FDA approved on April 22, 2020, as the brand Trodelvy under the accelerated approval designation for relapsed or refractory metastatic TNBC, and gained full approval for this indication on April 7, 2021. It was granted accelerated approval for metastatic urothelial cancer on April 13, 2021 (continued approval may be dependent on clinical trials showing a benefit) and full approval for metastatic HR+/HER2- breast cancer on February 3, 2023. There is no Trodelvy generic available.

Sacituzumab govitecan side effects

Sacituzumab govitecan can cause serious side effects, including:

The most common side effects of sacituzumab govitecan affecting 25% or more patients include:

These are not all of the possible side effects of sacituzumab govitecan. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Serious hypersensitivity and infusion-related reactions, including anaphylaxis, can occur with sacituzumab govitecan. Do not receive sacituzumab govitecan if you have had a severe allergic reaction to sacituzumab govitecan, Trodelvy, or any of the inactive ingredients in the injection.

Sacituzumab govitecan carries a black box warning for severe or life-threatening neutropenia and diarrhea.

Sacituzumab govitecan may cause nausea and vomiting, which can be severe. Your healthcare provider should prescribe antiemetic preventive treatment and withhold Sacituzumab govitecan for patients with Grade 3 nausea or Grade 3-4 vomiting at the time of treatment.

Patients with reduced UGT1A1 activity are at increased risk of side effects of sacituzumab govitecan such as low blood cell counts such as neutropenia (low levels of neutrophils – a type of white blood cell), febrile neutropenia, and anemia (low levels red blood cells).

Sacituzumab govitecan can cause fetal harm. Women of childbearing potential should use adequate contraception during treatment.

It is not known if sacituzumab govitecan is safe and effective in people with moderate or severe liver problems or in children.

Before taking

Before receiving sacituzumab govitecan, tell your healthcare provider about all of your medical conditions, including if you:


Sacituzumab govitecan can harm your unborn baby. Your healthcare provider should check to see if you are pregnant before you start receiving it. Females who can become pregnant should use effective birth control during treatment and for 6 months after their last dose. Talk to your healthcare provider about birth control choices that may be right for you during this time. Tell your healthcare provider right away if you become pregnant during treatment with sacituzumab govitecan.

Sacituzumab govitecan may cause fertility problems in females, which could affect your ability to have a baby. Talk to your healthcare provider if fertility is a concern for you.

Males with a female partner who can become pregnant should use effective birth control during treatment and for 3 months after their last dose of sacituzumab govitecan.

Tell your healthcare provider right away if you or your partner become pregnant during treatment with sacituzumab govitecan.


It is not known if sacituzumab govitecan passes into your breastmilk and can harm your baby. Do not breastfeed during treatment and for 1 month after your last dose.

How is sacituzumab govitecan administered?

Your healthcare provider will give you sacituzumab govitecan into your vein through an intravenous (IV) line, as an infusion initially over 3 hours. If you tolerate the first dose well, future doses may be given over 1 to 2 hours.

Your healthcare provider will decide how long you will continue to receive sacituzumab govitecan.

Dosing information

The recommended dose of sacituzumab govitecan is 10 mg/kg once weekly on Days 1 and 8 of continuous 21-day treatment cycles.

See the Full Prescribing information for further details about sacituzumab govitecan dosing.

What happens if I miss a dose?

If you miss or forget an appointment for sacituzumab govitecan, call your doctor or infusion center immediately to reschedule your infusion. It is important not to miss a planned appointment. Do not skip an appointment.

What other drugs affect sacituzumab govitecan?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain medicines may affect the way sacituzumab govitecan works.

See the prescribing information for a full list of interactions.


Store vials in a refrigerator at 2°C to 8°C (36°F to 46°F) in the original carton to protect them from light until the time of reconstitution. Do not freeze.

Sacituzumab govitecan is a hazardous drug. Follow applicable special handling and disposal procedures.

Trodelvy ingredients

Active ingredient: sacituzumab govitecan-hziy

Inactive ingredients: 2-(N-morpholino) ethane sulfonic acid (MES), polysorbate 80, and trehalose dihydrate


Trodelvy: Gilead Sciences, Inc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.