Medically reviewed by Drugs.com. Last updated on Aug 5, 2020.

• Pharmacology
• Uses
• Contraindications
• Dosage
• Storage
• Interactions
• Warnings
• Pregnancy
• Patient education

Pronunciation

(sye METH i kone)

Index Terms

• Activated Methylpolysiloxane

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

Gas Relief Extra Strength: 125 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #10 (quinoline yellow)]

Gas Relief Ultra Strength: 180 mg [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

Gas Relief Ultra Strength: 180 mg [contains fd&c yellow #6 (sunset yellow)]

Gas-X Extra Strength: 125 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #10 (quinoline yellow)]

Gas-X Ultra Strength: 180 mg [contains fd&c yellow #6 (sunset yellow)]

Phazyme: 180 mg

Phazyme Maximum Strength: 250 mg [contains brilliant blue fcf (fd&c blue #1)]

Phazyme Ultra Strength: 180 mg [contains fd&c yellow #6 (sunset yellow)]

Generic: 125 mg, 180 mg

Liquid, Oral:

Gas-X Infant Drops: 20 mg/0.3 mL (30 mL) [alcohol free, no artificial color(s), no artificial flavor(s), saccharin free; contains polyethylene glycol, sodium benzoate]

Strip, Oral:

Gas-X Childrens: 40 mg (16 ea) [contains alcohol, usp, fd&c red #40; sweet cinnamon flavor]

Gas-X Extra Strength: 62.5 mg (18 ea [DSC], 30 ea [DSC]) [contains alcohol, usp, brilliant blue fcf (fd&c blue #1); peppermint flavor]

Gas-X Extra Strength: 62.5 mg (18 ea) [contains alcohol, usp, fd&c red #40]

Suspension, Oral:

Gas Relief: 20 mg/0.3 mL (30 mL) [dye free; contains sodium benzoate; fruit flavor]

Gas Relief Infants: 20 mg/0.3 mL (30 mL) [dye free; contains sodium benzoate]

Infants Gas Relief: 20 mg/0.3 mL (30 mL) [contains sodium benzoate]

Infants Gas Relief: 20 mg/0.3 mL (30 mL) [dye free; contains sodium benzoate]

Infants Simethicone: 20 mg/0.3 mL (30 mL) [alcohol free, no artificial color(s), no artificial flavor(s), saccharin free; contains polyethylene glycol, sodium benzoate]

Generic: 40 mg/0.6 mL (30 mL)

Tablet Chewable, Oral:

Gas Relief: 80 mg

Gas Relief: 80 mg [lactose free]

Gas Relief Extra Strength: 125 mg

Gas Relief Extra Strength: 125 mg [contains fd&c red #40 aluminum lake]

Gas Relief Extra Strength: 125 mg [lactose free; contains fd&c yellow #10 aluminum lake]

Gas Relief Maximum Strength: 125 mg [DSC] [scored; lactose free; spearmint flavor]

Gas-X: 80 mg [DSC] [scored; peppermint creme flavor]

Gas-X Extra Strength: 125 mg [DSC]

Gas-X Extra Strength: 125 mg [DSC] [scored; peppermint creme flavor]

Gas-X Extra Strength: 125 mg [contains fd&c yellow #10 aluminum lake; peppermint creme flavor]

Gas-X Extra Strength: 125 mg [contains soy protein]

Gas-X Extra Strength: 125 mg [contains soy protein; cherry cream flavor]

Mi-Acid Gas Relief: 80 mg

Mytab Gas: 80 mg [DSC] [peppermint flavor]

Mytab Gas Maximum Strength: 125 mg [DSC] [scored; peppermint flavor]

Phazyme: 125 mg [cool mint flavor]

Phazyme: 125 mg [contains aspartame; cool mint flavor]

Generic: 80 mg, 125 mg

Brand Names: U.S.

• Gas Relief Extra Strength [OTC]
• Gas Relief Infants [OTC]
• Gas Relief Maximum Strength [OTC] [DSC]
• Gas Relief Ultra Strength [OTC]
• Gas Relief [OTC]
• Gas-X Childrens [OTC]
• Gas-X Extra Strength [OTC]
• Gas-X Infant Drops [OTC]
• Gas-X Ultra Strength [OTC]
• Gas-X [OTC] [DSC]
• Infants Gas Relief [OTC]
• Infants Simethicone [OTC]
• Mi-Acid Gas Relief [OTC]
• Mytab Gas Maximum Strength [OTC] [DSC]
• Mytab Gas [OTC] [DSC]
• Phazyme Maximum Strength [OTC]
• Phazyme Ultra Strength [OTC]
• Phazyme [OTC]

Pharmacologic Category

• Antiflatulent

Pharmacology

Decreases the surface tension of gas bubbles thereby disperses and prevents gas pockets in the GI system

Excretion

Feces

Use: Labeled Indications

Gas retention: Relief of pressure, bloating, fullness, and discomfort of gastrointestinal gas.

Contraindications

Hypersensitivity to simethicone or any component of the formulation

Dosing: Adult

Gas retention: Oral: Usual dose: 40 to 125 mg 4 times daily as needed after meals and at bedtime; may administer single doses of up to 160 to 500 mg after meals or at bedtime, not to exceed a maximum daily dose of 500 mg/day

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Note: Refer to product specific labeling for approved pediatric ages.

Gas pain/ gastrointestinal discomfort:

Infants and Children <2 years weighing <10.9 kg: Oral: 20 mg 4 times daily as needed after meals and at bedtime. Maximum daily dose: 240 mg/24 hours

Children <2 years weighing ≥10.9 kg and Children ≥2 to <12 years: Oral: 40 mg 4 times daily as needed after meals and at bedtime. Maximum daily dose: 480 mg/24 hours

Children ≥12 years and Adolescents: 40 to 125 mg 4 times daily as needed after meals and at bedtime; with some formulations, may administer a single 250 mg dose if needed; maximum daily dose: 500 mg/24 hours

Administration

Oral: Chewable tablet: Chew thoroughly and swallow

Oral suspension (drops): Shake well before using; may mix with 30 mL water or other liquids.

Oral strips: Allow to dissolve on tongue.

Storage

Store at 20°C to 25°C (68°F to 77°F). Protect from moisture. Avoid high humidity and excessive heat.

Oral suspension: Do not freeze.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

No data reported

Warnings/Precautions

Dosage form specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain sodium benzoate/benzoic acid; benzoic acid (benzoate) is a metabolite of benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC, 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors, 2001); avoid or use dosage forms containing benzyl alcohol derivative with caution in neonates. See manufacturer’s labeling.

Pregnancy Considerations

Simethicone is physiologically inert and not absorbed systemically following oral administration (Danhof 1974).

Patient Education

What is this drug used for?

• It is used to ease too much gas in the GI (gastrointestinal) tract.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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