Skip to Content

Alcaftadine

Medically reviewed by Drugs.com. Last updated on May 18, 2020.

Pronunciation

(al KAF ta deen)

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic:

Lastacaft: 0.25% (3 mL) [contains benzalkonium chloride, edetate disodium]

Brand Names: U.S.

  • Lastacaft

Pharmacologic Category

  • Histamine H1 Antagonist
  • Histamine H1 Antagonist, Second Generation
  • Mast Cell Stabilizer

Pharmacology

Direct H1-receptor antagonist and inhibitor of histamine release from mast cells

Absorption

Minimal systemic absorption

Metabolism

Non-CYP450 cytosolic enzymes to the active metabolite carboxylic acid

Half-Life Elimination

Carboxylic acid: ~2 hours

Protein Binding

~40%; Carboxylic acid (metabolite): ~60%

Use: Labeled Indications

Allergic conjunctivitis: Prevention of itching associated with allergic conjunctivitis

Contraindications

Hypersensitivity to alcaftadine or any component of the formulation.

Dosing: Adult

Allergic conjunctivitis: Ophthalmic: Instill 1 drop into each eye once daily.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Allergic conjunctivitis: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop in each eye once daily

Administration

For topical ophthalmic use only. Contact lenses should be removed prior to application, and may be reinserted 10 minutes after administration. Separate administration of other ophthalmic agents by 5 minutes. Do not insert contacts if eyes are red. Avoid contaminating the applicator tip with affected eye(s).

Storage

Store at 15°C to 25°C (59°F to 77°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

1% to 10%:

Central nervous system: Headache (<3%)

Ophthalmic: Burning sensation of eyes (<4%), eye irritation (<4%), eye pruritus (<4%), eye redness (<4%), stinging of eyes (<4%)

Respiratory: Nasopharyngitis (<3%)

<1%, postmarketing, and/or case reports: Allergic dermatitis, blurred vision, drowsiness, erythema of eyelid, eye discharge, eyelid edema, facial edema, hypersensitivity, increased lacrimation, swelling of eye

Warnings/Precautions

Special populations:

• Contact lens wearers: Contains benzalkonium chloride which may be absorbed by soft contact lenses; remove lenses prior to administration and wait 10 minutes before reinserting. Not for the treatment of contact lens irritation; do not wear contact lens if eye is red.

Other warnings/precautions:

• Appropriate use: For topical ophthalmic use only. To avoid eye injury and contamination, do not touch dropper tip to eyelids or any surface.

Pregnancy Considerations

Adverse events were not observed in animal reproduction studies.

If ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctal occlusion to decrease potential exposure to the fetus (Samples 1988).

Patient Education

What is this drug used for?

• It is used to treat eye irritation due to allergies.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache

• Burning

• Stinging

• Redness

• Stuffy nose

• Sore throat

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Vision changes

• Eye pain

• Severe eye irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.