Taletrectinib

Generic name: taletrectinib [ TA-le-TREK-tin-ib ]
Brand name: Ibtrozi
Dosage form: oral capsule (200 mg)
Drug class: Multikinase inhibitors

Medically reviewed by Drugs.com on Jul 8, 2025. Written by Cerner Multum.

What is taletrectinib?

Taletrectinib is used in adults to treat non-small cell lung cancer that has spread within your chest or to other parts of the body (metastatic).

Your doctor will make sure you have the correct tumor type to be treated with taletrectinib.

Taletrectinib may also be used for purposes not listed in this medication guide.

Taletrectinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Taletrectinib may cause serious side effects. Call your doctor at once if you have:

• sudden pain or trouble moving your hip, wrist, or back;

• heart problems--swelling, rapid weight gain, feeling short of breath, fast or pounding heartbeats, fluttering in your chest, or sudden dizziness (like you might pass out);

• high levels of uric acid in blood--joint problems, stomach pain, little or no urination, nausea, vomiting, pink or brown urine;

• lung problems--sudden chest pain, wheezing, dry cough, feeling short of breath;

• muscle problems--unexplained muscle pain, tenderness, weakness; or

• liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of taletrectinib may include:

• nausea, vomiting, diarrhea, constipation;

• abnormal blood tests;

• dizziness, tiredness; or

• rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

Tell your doctor if you have or have ever had:

• gout or high levels of uric acid in the blood;

• heart problems, including long QT syndrome (in you or a family member);

• lung or breathing problems (other than lung cancer); or

• liver disease.

You may be more likely to have a broken bone while using taletrectinib. Talk with your doctor about ways to keep your bones healthy.

Taletrectinib can harm an unborn baby if the mother or the father is using taletrectinib.

• If you are a woman, you will need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 3 weeks after your last dose.

• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control during treatment and for at least 3 weeks after your last dose.

• Tell your doctor right away if a pregnancy occurs.

Do not breastfeed while using this medicine, and for at least 3 weeks after your last dose.

Taletrectinib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

How should I take taletrectinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor will perform tests to make sure taletrectinib is the right treatment for you.

Taletrectinib is usually taken once per day, but take it the same way each time.

Take on an empty stomach, at least 2 hours before or 2 hours after a meal.

Do not change your dose or stop taking taletrectinib without your doctor's advice.

Swallow the capsule whole and do not crush, chew, break, or open it.

If you vomit shortly after taking taletrectinib, do not take another dose. Take your next dose as scheduled.

You will need frequent medical tests including tests to check your liver and heart function. Your cancer treatments may change, be delayed or discontinued based on the results.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking taletrectinib?

Taletrectinib could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors while using taletrectinib and for at least 5 days after your last dose.

Ask your doctor before taking an antacid, and take only the type your doctor recommends.

Grapefruit may interact with taletrectinib and cause side effects. Avoid consuming grapefruit products.

What other drugs will affect taletrectinib?

Avoid taking an antacid within 2 hours before or after you take taletrectinib.

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Taletrectinib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all your current medicines. Many drugs can affect taletrectinib, especially:

• stomach acid reducers such as omeprazole, pantoprazole, famotidine.

This list is not complete and many other drugs may affect taletrectinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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