Generic Name: trientine (TRYE en teen)
Brand Name: Syprine
What is Syprine (trientine)?
Trientine is a chelating (KEE-late-ing) agent. A chelating agent works by removing a heavy metal (such as lead, mercury, or copper) from the blood.
Wilson's disease is a genetic metabolic defect that causes excess copper to build up in the body.
Trientine is used to treat this inherited condition in people who cannot take penicillamine.
Trientine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Syprine (trientine)?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What should I discuss with my health care provider before taking Syprine (trientine)?
You should not use this medication if you are allergic to trientine.
To make sure trientine is safe for you, tell your doctor if you have:
anemia (low red blood cells); or
a liver condition called biliary cirrhosis.
FDA pregnancy category C. It is not known whether trientine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether trientine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take Syprine (trientine)?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take trientine on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not drink milk, eat food, or take any other medications for at least 1 hour after you take trientine.
Do not chew, break, or open a trientine capsule. Swallow it whole.
The medicine from a broken pill can be irritating if it gets on your skin. If this occurs, wash your skin with water right away. Ask your doctor or pharmacist how to safely handle and dispose of a broken capsule.
Your doctor may have you take extra iron while you are taking trientine. Take only the amount of iron that your doctor has prescribed.
Call your doctor if you have a fever or a skin rash while taking this medicine. You may need to take your temperature every night for the first month of treatment with trientine.
While using trientine, you may need frequent blood and urine tests. You should remain under the care of a doctor during treatment.
Store in the refrigerator, do not freeze. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Syprine (trientine)?
Ask your doctor before using a vitamin or mineral supplement, and use only the type your doctor recommends. Some minerals can make it harder for your body to absorb trientine.
Syprine (trientine) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fever or skin rash;
problems with speech, balance, walking, lifting, chewing, or swallowing;
muscle pain or stiffness;
muscle weakness, drooping eyelids, double vision; or
symptoms of lupus (an autoimmune disorder)--joint pain or swelling, headaches, confusion, chest pain, shortness of breath, skin sores, or numbness, cold feeling, or pale appearance of your fingers or toes.
Common side effects may include:
heartburn, stomach pain, loss of appetite;
black, tarry stools;
general ill feeling;
mouth sores; or
skin flaking, cracking, or thickening.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Syprine (trientine)?
Other drugs may interact with trientine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about Syprine (trientine)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about trientine.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01.
Date modified: November 30, 2016
Last reviewed: December 15, 2013