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Syprine Side Effects

Generic Name: trientine

Note: This page contains side effects data for the generic drug trientine. It is possible that some of the dosage forms included below may not apply to the brand name Syprine.

For the Consumer

Applies to trientine: oral capsule

As well as its needed effects, trientine (the active ingredient contained in Syprine) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking trientine, check with your doctor or nurse as soon as possible:

More common: - Symptoms of anemia
  • Unusually pale skin
  • unusual tiredness
  • Fever
  • general feeling of discomfort, illness, or weakness
  • joint pain
  • skin rash, blisters, hives, or itching
  • swollen glands

Note: Signs of anemia are more likely to occur in children, menstruating women, and pregnant women, who usually need more iron than other patients. If these signs appear during trientine treatment, your doctor will need to do some tests.

For Healthcare Professionals

Applies to trientine: oral capsule

Nervous system

Frequency not reported: Myasthenia gravis[Ref]


Frequency not reported: Nausea, duodenitis, severe colitis, heartburn, epigastric pain and tenderness, acute gastritis, aphthoid ulcers, abdominal pain, melena[Ref]


Very rare (less than 0.01%): Anemia, hypochromic microcytic anemia[Ref]


Frequency not reported: Systemic lupus erythematosus, dystonia, muscular spasm, cramps, muscle pain, rhabdomyolysis[Ref]


Frequency not reported: Iron deficiency, anorexia[Ref]


Frequency not reported: Skin rash, thickening/fissuring/flaking of the skin[Ref]


Frequency not reported: Malaise, weakness[Ref]


1. "Product Information. Syprine (trientine)." Aton Pharma, Lawrenceville, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Syprine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.