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Sildenafil (injection)

Generic name: sildenafil (injection) [ sil-DEN-a-fil ]
Brand name: Revatio
Dosage form: intravenous solution (10 mg/12.5 mL)
Drug classes: Agents for pulmonary hypertension, Impotence agents

Medically reviewed by Drugs.com on Oct 7, 2024. Written by Cerner Multum.

What is sildenafil?

Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.

Sildenafil injection (Revatio) is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Another brand of sildenafil is Viagra, which is used to treat erectile dysfunction (impotence) in men. Revatio is used to treat PAH in both men and women.

Do not use sildenafil injection while also taking Viagra or other erectile dysfunction medications, unless your doctor tells you to.

Sildenafil injection may also be used for purposes not listed in this medication guide.

Injectable sildenafil side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using sildenafil and get emergency medical help if you have:

Sildenafil may cause serious side effects. Call your doctor at once if you have:

Common side effects of sildenafil may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas).

Do not use sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers." Using sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Do not use sildenafil injection with Viagra similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra). Tell your doctor about all medications you use for erectile dysfunction.

Get emergency medical help if you have ringing in your ears, sudden hearing loss, or sudden vision loss.

Before taking this medicine

You should not use sildenafil injection if you are allergic to it, or:

Do not use sildenafil injection if you are also taking a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Using sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

To make sure sildenafil is safe for you, tell your doctor if you have ever had:

Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people using sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear whether sildenafil is the actual cause of vision loss.

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medication to anyone under 18 years old without medical advice.

How should I use injectable sildenafil?

This medicine is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject sildenafil if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Sildenafil injection is usually given three times each day. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. These conditions may cause very low blood pressure. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Store at room temperature away from moisture and heat.

sildenafil, tadalafil, Cialis, Viagra, alprostadil, Adcirca, Levitra, ambrisentan, Opsumit, Revatio

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using injectable sildenafil?

Avoid using other medicines to treat impotence without your doctor's advice.

What other drugs will affect injectable sildenafil?

Do not use Revatio with Viagra or similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra). Tell your doctor about all medications you use for erectile dysfunction.

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Does sildenafil interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Frequently asked questions

View more FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.