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Saizen

Generic Name: somatropin (soe ma TROE pin)
Brand Name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive

Medically reviewed: November 21, 2017

What is Saizen?

Saizen is a form of human growth hormone important for the growth of bones and muscles.

Saizen is used to treat growth failure in children and adults who lack natural growth hormone. This includes people with with chronic kidney failure, Noonan syndrome, Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up growth, and other causes.

Saizen is also used in adults to treat short bowel syndrome, or to prevent severe weight loss related to AIDS.

Saizen may also be used for purposes not listed in this medication guide.

Important Information

You should not use Saizen if you have cancer, diabetic retinopathy, or if you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems. You should not use this medicine if you have a serious illness due to lung failure or complications from recent surgery, injury, or medical trauma.

Before taking this medicine

You should not use this medicine if you are allergic to Saizen or benzyl alcohol, or if you have:

  • a serious illness due to lung failure, or complications from recent surgery, injury, or medical trauma;

  • active cancer;

  • eye problems caused by diabetes (diabetic retinopathy); or

  • if you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems (including sleep apnea).

To make sure Saizen is safe for you, tell your doctor if you have ever had:

Some brands of Saizen are not expected to harm an unborn baby, including Genotropin, Omnitrope, Saizen, and Serostim.

It is not known whether certain other brands of Saizen will harm an unborn baby, including Humatrope, Norditropin, Nutropin, Zomacton, and Zorbtive.

Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether Saizen passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Saizen?

Your dose and brand of Saizen, and how often you use it will depend on the condition you are treating. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

In some cases, Saizen should not be used in a child. Certain brands of this medicine contain an ingredient that can cause serious side effects or death in very young infants or premature babies. Do not allow an older child to use this medicine without supervision of an adult.

Saizen is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.

Your care provider will show you the best places on your body to inject Saizen. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

Do not shake the medication bottle or you may ruin the medicine. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

While using Saizen, you may need frequent blood tests. Your growth progress will need to be tested often. Your eyes and your skin may also need to be checked.

If you are being treated for short bowel syndrome, follow the diet plan created for you by your doctor or nutrition counselor to help control your condition. Saizen is not a cure for short bowel syndrome.

If you have Prader-Willi syndrome, your treatment program may also include weight control. Follow your doctor's instructions very closely.

If you use a form of Saizen that comes in a cartridge for use with an injection pen, use only the pen injection system provided with the this medicine brand you use.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

How you store this medicine will depend on the Saizen brand and the diluent you are using. After mixing this medicine, you may need to use it right away or you may be able to store it for later use. Read and carefully follow the instructions provided with your medicine about proper storage of this medicine before and after it has been mixed. Ask your pharmacist if you have any questions about proper storage of your medication.

Throw away any Saizen left over after the expiration date on the label has passed.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Call your doctor if you miss more than 3 doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.

What should I avoid while using Saizen?

If you use Zorbtive to treat short bowel syndrome, avoid drinking fruit juices or soda beverages. elor about what types of liquids you should drink while using Zorbtive.

Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.

Saizen side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious breathing problems may occur in patients with Prader-Willi syndrome who use Saizen. If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring.

Also call your doctor at once if you have:

  • pain in your knees or hips, walking with a limp;

  • ear pain, swelling, warmth, or drainage;

  • numbness or tingling in your wrist, hand, or fingers;

  • severe swelling or puffiness in your hands and feet;

  • pain or swelling in your joints;

  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision;

  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or

  • signs of an adrenal gland problem--extreme weakness, severe dizziness, weight loss, changes in skin color, feeling very weak or tired.

Common side effects may include:

  • swelling, rapid weight gain;

  • muscle or joint pain;

  • stomach pain, gas;

  • headache; or

  • pain, itching, or skin changes where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Saizen?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with somatropin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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