Generic Name: sacituzumab govitecan (SAK i TOOZ ue mab GOE vi TEE kan)
Brand Name: Trodelvy
Dosage Forms: intravenous powder for injection (180 mg)
What is sacituzumab govitecan?
Sacituzumab govitecan is used to treat HR-negative and HER2-negative (sometimes called triple-negative) breast cancer in adults.
sacituzumab govitecan is used when the cancer has spread to other parts of the body (metastatic), after at least two other cancer treatments did not work or have stopped working.
Sacituzumab govitecan was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.
Sacituzumab govitecan may also be used for purposes not listed in this medication guide.
Sacituzumab govitecan affects your immune system. You may get infections more easily, even serious or fatal infections. Tell your doctor if you have a fever, chills, pain or burning when you urinate, cough, or trouble breathing.
Tell your doctor right away the first time you have diarrhea while receiving this medicine, or if you have black or bloody stools, if you feel light-headed, if you can't keep liquids down because of vomiting, or if you can't get your diarrhea to stop within 24 hours.
Before taking this medicine
You should not be treated with sacituzumab govitecan if you have ever had a severe allergic reaction to it.
Tell your doctor if you have ever had:
liver disease; or
if you've been told that you carry a gene called UGT1A1*28, which may increase your risk of getting infections while using sacituzumab govitecan.
You will need to have a negative pregnancy test before receiving sacituzumab govitecan.
Sacituzumab govitecan can harm an unborn baby if the mother or the father is using sacituzumab govitecan.
If you are a woman, do not use sacituzumab govitecan if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using sacituzumab govitecan.
This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because sacituzumab govitecan can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 month after your last dose.
How is sacituzumab govitecan given?
Sacituzumab govitecan is given as an infusion into a vein. A healthcare provider will give you this injection.
Sacituzumab govitecan is given in a 21-day treatment cycle. You will receive the medicine only during the first 2 weeks of each cycle.
This medicine must be given slowly, and the infusion can take 1 to 3 hours to complete.
You will be watched closely for at least 30 minutes to make sure you do not have an allergic reaction.
You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
Sacituzumab govitecan commonly causes diarrhea. Severe diarrhea can lead to dehydration, which may require medical treatment. Tell your doctor right away the first time you have diarrhea while receiving this medicine.
Sacituzumab govitecan affects your immune system. You may get infections more easily, even serious or fatal infections. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.
Your doctor will determine how long to treat you with this medicine.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your sacituzumab govitecan injection.
What happens if I overdose?
Since sacituzumab govitecan is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving sacituzumab govitecan?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Sacituzumab govitecan side effects
sacituzumab govitecan can cause severe or life-threatening allergic reactions.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection or within 24 hours afterward. Tell your caregiver if you feel dizzy, light-headed, itchy, sweaty, or have a fever, chills, trouble breathing, or swelling in your face or throat.
You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have:
pain or burning when you urinate;
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing.
Sacituzumab govitecan can cause severe diarrhea. Tell your doctor right away if you have:
diarrhea (the first time it occurs);
diarrhea lasting longer than 24 hours (even if you use anti-diarrhea medicine);
black or bloody stools;
severe or ongoing vomiting, especially if you can't keep liquids down; or
a light-headed feeling, like you might pass out.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
diarrhea, nausea, vomiting;
stomach pain, loss of appetite, constipation;
low blood cell counts;
hair loss; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect sacituzumab govitecan?
Other drugs may affect sacituzumab govitecan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
More about sacituzumab govitecan
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: miscellaneous antineoplastics
- Other brands
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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