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Generic name: dinoprostone topicalDYE-no-PROS-tone-TOP-ik-al ]
Brand names: Cervidil, Prepidil, Prostin E2
Drug class: Uterotonic agents

Medically reviewed by on Aug 9, 2023. Written by Cerner Multum.

What is Prepidil?

Dinoprostone is a prostaglandin, a hormone-like substance that is naturally produced by tissues in the body.

Prepidil is used in a pregnant woman to relax the muscles of the cervix (opening of the uterus) in preparation for inducing labor at the end of a pregnancy.

Prepidil may be used for purposes not listed in this medication guide.

Prepidil side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if your contractions slow down or become uneven, or if you have:

Common side effects of Prepidil may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not be treated with Prepidil if you are allergic to prostaglandins, or if you have active genital herpes with a vaginal lesion, placenta previa, or if your water has broken.

Be sure your doctor knows your entire pregnancy history, especially if you have ever had a C-section or major surgery on your uterus, if you have had a baby born in a breech position, or if you have had a difficult labor or delivery of a previous child.

Before taking this medicine

You should not be treated with this medicine if you are allergic to prostaglandins, or if you have:

Be sure your doctor knows your entire pregnancy history, especially:

Tell your doctor if you have ever had:

Dinoprostone is not expected to be harmful to the unborn baby when used to induce labor.

You should not breastfeed while you are being treated with Prepidil.

How is Prepidil given?

Dinoprostone is a gel or suppository that is placed directly onto the cervix through the vagina using a special applicator. A healthcare provider will insert Prepidil at the correct time best prepare your cervix.

Dinoprostone is usually given while you are lying on your back. Your doctor may use a vaginal speculum to view your cervix. This will help your doctor determine how much of this medication to use.

You will need to remain lying down for 15 to 30 minutes, and possibly for up to 2 hours, unless your doctor tells you otherwise.

Your contractions and your baby's heartbeat will be constantly monitored after you are treated with dinoprostone. Your doctor will also check your cervix frequently to determine how much it has dilated.

Prepidil can cause contractions to occur more often and they may also last longer.

If your uterus responds to dinoprostone, you may begin having regular uterine contractions within a few hours. You may also be given other medications to help stimulate your uterine contractions and make them more regular.

If your uterus does not respond to dinoprostone within 6 hours, your doctor may apply a second dose.

A Prepidil suppository is usually removed once you begin labor, or 12 hours after the medicine was inserted.

What happens if I miss a dose?

Since dinoprostone is used when needed in a clinical setting, it does not have a daily dosing schedule.

What happens if I overdose?

Since Prepidil is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Prepidil?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Prepidil?

Other drugs may affect dinoprostone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.