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Prepidil Side Effects

Generic name: dinoprostone topical

Medically reviewed by Last updated on Nov 17, 2023.

Note: This document contains side effect information about dinoprostone topical. Some dosage forms listed on this page may not apply to the brand name Prepidil.

Applies to dinoprostone topical: vaginal gel/jelly, vaginal insert extended release.


Vaginal route (Suppository)

Dinoprostone should be used with strict adherence to recommended dosages and only by medically trained personnel in a hospital setting that can provide immediate intensive care and acute surgical facilities.

Serious side effects of Prepidil

Along with its needed effects, dinoprostone topical (the active ingredient contained in Prepidil) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dinoprostone topical:

Less common or rare

Other side effects of Prepidil

Some side effects of dinoprostone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common or rare

This procedure may still result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if any of the following side effects occur while taking dinoprostone topical:

For Healthcare Professionals

Applies to dinoprostone topical: vaginal gel, vaginal insert, vaginal suppository.


Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, abdominal pain[Ref]


Very common (10% or more): Any fetal heart rate abnormality

Frequency not reported: Hearing impairment, neonatal distress, neonatal death, stillbirths, low Apgar score[Ref]


Common (1% to 10%): Hypotension, bradycardia

Frequency not reported: Flushing or hot flashes, chest pain, cardiac arrhythmia[Ref]

Nervous system

Uncommon (0.1% to 1%): Fever

Frequency not reported: Headache, dizziness, weakness, tremor, paresthesia[Ref]


Rare (0.01% to 0.1%): Postpartum disseminated intravascular coagulation

Frequency not reported: Elevated WBC[Ref]


Frequency not reported: Dehydration[Ref]


Frequency not reported: Back pain, joint inflammation or pain new or exacerbated, muscle cramp or pain, nocturnal leg cramps[Ref]


Frequency not reported: Dyspnea, coughing, pharyngitis, laryngitis, wheezing, tightness in chest, pharyngitis, laryngitis[Ref]


Frequency not reported: Rash, diaphoresis, skin discoloration[Ref]


Frequency not reported: Blurred vision, eye pain[Ref]


Frequency not reported: Anaphylactic reactions (including anaphylactic shock)[Ref]


Common (1% to 10%): Uterine hyperstimulation (with or without fetal distress), fetal distress without uterine hyperstimulation, warm feeling in vagina

Frequency not reported: Uterine hypertonus, uterine rupture, placenta abruptio, rapid cervical dilatation, vaginal pain, vaginal irritation, vaginitis or vulvitis, breast tenderness, vaginismus, genital edema, transient vasovagal symptoms (flushing, shivering, headache, dizziness)[Ref]


Frequency not reported: Tension[Ref]


1. (2022) "Product Information. Prostin E2 (dinoprostone topical)." Apothecon Inc

2. (2001) "Product Information. Prepidil (dinoprostone topical)." Pharmacia and Upjohn

3. (2002) "Product Information. Cervidil (dinoprostone topical)." Forest Pharmaceuticals

4. Cerner Multum, Inc. "UK Summary of Product Characteristics."

5. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.