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Generic name: sulfacetamide sodium topicalSUL-fa-SEET-a-mide-SOE-dee-um-TOP-i-kal ]
Brand names: Klaron, Ovace, Ovace Plus, Plexion NS, Mexar, Seb-Prev
Drug class: Topical antibiotics

Medically reviewed by on Nov 7, 2023. Written by Cerner Multum.

What is Ovace?

Ovace (for the skin) is used to treat acne, dandruff, seborrheic dermatitis (an inflammatory skin condition of the scalp), and certain skin infections in adults and children at least 12 years old.

Ovace may also be used for purposes not listed in this medication guide.

Ovace side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Ovace may cause serious side effects. Stop using Ovace and call your doctor at once if you have:

Common side effects of Ovace may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You may not be able to use Ovace if you are allergic to Ovace, other sulfa drugs, or if you have kidney disease.

Tell your doctor if you have or have ever had:

It is not known if Ovace will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Do not give this medicine to a child without medical advice.

How should I use Ovace?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using exactly as directed on the label, or as prescribed by your doctor.

Shake the Ovace lotion, cream, foam, liquid, or shampoo well before use.

Do not apply Ovace over large skin areas.

Wash your hands after applying this medicine.

Call your doctor if your condition comes back after you stop using Ovace or if you experience skin irritation or sensitive while using this medicine for long-term.

Store tightly closed at room temperature, away from moisture and heat. Do not freeze.

Store the foam canister upright and keep away from open flame or high heat. Do not puncture or burn an empty canister.

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.

Overdose symptoms may include nausea, vomiting, blood in your urine, or urinating less than usual.

What should I avoid while using Ovace?

Avoid getting Ovace in your eyes, nose, or mouth. Rinse with water if this medicine gets in your eyes, nose, or mouth.

Do not apply this medicine to broken skin, burns, peeling skin or to areas of infection unless your doctor tells you to.

Avoid getting this medicine on your clothing. Ovace may leave a slight discoloration on light fabrics.

What other drugs will affect Ovace?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Ovace, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about Ovace (sulfacetamide sodium topical)

Patient resources

Other brands

Klaron, Mexar, Seb-Prev

Professional resources

Other brands

Klaron, Plexion NS Shampoo, Seb-Prev

Other formulations

Related treatment guides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.