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Generic Name: lasmiditan (las MID i tan)
Brand Name: Reyvow
Dosage Forms: oral tablet (100 mg; 50 mg)

Medically reviewed by on July 29, 2020. Written by Cerner Multum.

What is lasmiditan?

Lasmiditan is used in adults to treat migraine headaches with or without aura.

Lasmiditan will only treat and will not prevent a migraine headache.

Lasmiditan may also be used for purposes not listed in this medication guide.


Do not take more than one dose in a 24-hour period.

For at least 8 hours after taking lasmiditan, do not drive and avoid other hazardous activity.

Before taking this medicine

Tell your doctor if you have ever had:

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with lasmiditan and cause a serious condition called serotonin syndrome.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether lasmiditan will harm an unborn baby. However, having migraine headaches during pregnancy may cause complications such as eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating migraines may outweigh any risks to the baby.

It may not be safe to breastfeed while using lasmiditan. Ask your doctor about any risk.

Lasmiditan is not approved for use by anyone younger than 18 years old.

How should I take lasmiditan?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Lasmiditan may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Take lasmiditan soon as you notice headache symptoms.

Do not take more than one dose in a 24-hour period.

You may take lasmiditan with or without food.

Call your doctor if your headache does not go away completely, or if you have more than 4 headaches in one month (30 days).

Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.

Store at room temperature away from moisture and heat.

Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

What happens if I miss a dose?

Since lasmiditan is used once when needed, it does not have a daily dosing schedule. Call your doctor if your migraine symptoms do not improve after using lasmiditan.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking lasmiditan?

After taking lasmiditan, do not drive for at least 8 hours, and avoid other hazardous activity. Your reactions could be impaired, and you may not realize the extent of that impairment.

Drinking alcohol with lasmiditan can cause side effects.

Lasmiditan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lasmiditan dosing information

Usual Adult Dose for Migraine:

Initial dose: 50 mg, 100 mg, or 200 mg orally once
Maximum dose: 1 dose per day

-This drug should not be taken unless the patient can wait 8 hours or more before driving or operating machinery.
-No more than 1 dose should be taken in 24 hours; a second dose has not been shown to be effective for the same migraine attack.
-The safety of treating an average of more than 4 migraine attacks in a 30-day period has not been established.
-This drug is not indicated for the prevention of migraine attacks.

Use: For the acute treatment of migraine with or without aura.

What other drugs will affect lasmiditan?

Using lasmiditan with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Many drugs can affect lasmiditan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.