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Interferon beta-1b

Generic Name: interferon beta-1b (in ter FEAR on BAY ta 1b)
Brand Name: Betaseron, Extavia

Medically reviewed by Drugs.com on Oct 3, 2018 – Written by Cerner Multum

What is interferon beta-1b?

See also: Xeloda

Interferon beta-1b is used to treat is used to treat relapsing forms of multiple sclerosis (MS). interferon beta-1b will not cure MS, it will only decrease the frequency of relapse symptoms.

Interferon beta-1b may also be used for purposes not listed in this medication guide.

Important Information

Some people have depression or thoughts about suicide while using interferon beta-1b. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, trouble sleeping, hallucinations, or if you feel impulsive, hostile, aggressive, depressed, or have thoughts about suicide or hurting yourself.

Interferon beta-1b can harm your liver. Call your doctor at once if you have nausea, vomiting, tiredness, itching, dark urine, or jaundice (yellowing of your skin or eyes).

Before taking this medicine

You should not use interferon beta-1b if you are allergic to interferon beta, albumin, or mannitol.

Tell your doctor if you have ever had:

  • liver disease;

  • congestive heart failure;

  • a seizure;

  • depression, anxiety, or suicidal behavior;

  • a bleeding or blood-clotting disorder;

  • low white blood cell (WBC) counts; or

  • anemia (lack of red blood cells).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I use interferon beta-1b?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Interferon beta-1b is injected under the skin, usually every other day. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use interferon beta-1b if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

You will need frequent medical tests.

Store unmixed medicine at cool room temperature away from moisture and heat.

After mixing interferon beta-1b, store in the refrigerator and use within 3 hours. Do not freeze.

Each single-use vial (bottle) of this medicine is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Then wait at least 48 hours before using another injection, and restart your dosing schedule at that time. Do not use more than one injection every 48 hours (2 days).

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using interferon beta-1b?

Avoid injecting interferon beta-1b into skin that is sore, red, or infected.

Drinking alcohol with this medicine can cause serious side effects.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Interferon beta-1b side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some patients using interferon medicines have become very depressed or had thoughts of suicide. Report any new or worsening symptoms of depression to your doctor, such as: mood or behavior changes, anxiety, trouble sleeping, hallucinations, or if you feel impulsive, hostile, aggressive, depressed, or have thoughts about suicide or hurting yourself.

Stop using interferon beta-1b and call your doctor at once if you have:

  • fever, chills, body aches, flu symptoms;

  • a seizure;

  • pain, swelling, redness, or skin changes where an injection was given;

  • easy bruising, unusual bleeding, purple or red spots under your skin;

  • heart problems--swelling, rapid weight gain, feeling short of breath;

  • liver problems--nausea, vomiting, tiredness, itching, dark urine, jaundice (yellowing of your skin or eyes); or

  • new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Common side effects may include:

  • headache, weakness;

  • sleep problems (insomnia);

  • stomach pain;

  • muscle pain;

  • abnormal liver function tests;

  • skin rash;

  • flu symptoms; or

  • a skin reaction where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interferon beta-1b dosing information

Usual Adult Dose for Multiple Sclerosis:

Initial dose: 0.0625 mg subcutaneously every other day, and increased (in 25% increments) every 2 weeks, over a 6 week period, to maintenance dose
Maintenance dose: 0.25 mg subcutaneously every other day

Schedule for dose titration:
Weeks 1 and 2: 0.0625 mg subcutaneously every other day (25% of recommended dose)
Weeks 3 and 4: 0.125 mg subcutaneously every other day (50% of recommended dose)
Weeks 5 and 6: 0.1875 mg subcutaneously every other day (75% of recommended dose)
Week 7 and beyond: 0.25 mg subcutaneously every other day (100% of recommended dose)

Use: For the treatment of relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations. Patients with multiple sclerosis in whom efficacy has been demonstrated include patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.

What other drugs will affect interferon beta-1b?

Other drugs may affect interferon beta-1b, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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