Hycamtin (oral/injection)

Generic name: topotecan (oral/injection) [ TOE-poe-TEE-kan ]
Other brand names of topotecan (oral/injection) include Hycamtin
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Apr 7, 2025. Written by Cerner Multum.

What is Hycamtin?

Hycamtin is used to treat ovarian cancer, small cell lung cancer, and certain types of cervical cancer.

Hycamtin is usually given after other treatments have failed.

Hycamtin may also be used for purposes not listed in this medication guide.

Hycamtin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hycamtin may cause serious side effects. Call your doctor at once if you have:

• new or worsening cough, fever, trouble breathing;

• diarrhea with fever and stomach cramps;

• pain or burning when you urinate;

• signs of pneumonia--fever, chills, cough with mucus, chest pain, feeling short of breath; or

• low blood cell counts--fever, chills, flu-like symptoms, mouth sores, skin sores, pale skin, cold hands and feet, bruising or bleeding, feeling light-headed.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Hycamtin may include:

• low blood cell counts;

• trouble breathing, pneumonia

• nausea, diarrhea, vomiting, stomach pain;

• loss of appetite;

• hair loss; or

• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Hycamtin affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, cough, diarrhea, stomach cramps, pain or burning when you urinate).

Before taking this medicine

You should not use Hycamtin if you are allergic to it.

Tell your doctor if you have ever had:

• severe diarrhea;

• kidney disease;

• lung problems; or

• a chest X-ray or radiation treatment of your chest area.

Hycamtin can harm an unborn baby or cause birth defects if the mother or the father is using Hycamtin.

• If you are a woman, do not use Hycamtin if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Hycamtin.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Hycamtin may harm the baby if a pregnancy does occur.

You should not breastfeed while using Hycamtin, and for at least 1 week after your last dose.

How should I use Hycamtin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Hycamtin capsules are taken by mouth, with or without food. You may need to take two different colored capsules at one time. Make sure you know the difference between capsules because one contains 4 times as much this medicine as the other, even though they may look the same in size.

If you vomit after taking a Hycamtin capsule, do not take another dose that same day.

Do not use a broken or opened capsule. The medicine from a broken pill can be dangerous if it gets in your eyes or on your skin. If this happens, wash your skin with soap and water or rinse your eyes with water for at least 15 minutes. Then call your doctor.

Store Hycamtin capsules in the refrigerator and protect them from light.

Hycamtin injection is given as an infusion into a vein. A healthcare provider will give you this injection. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when this medicine is injected.

Hycamtin can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

Your doctor will determine how long to treat you with Hycamtin.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Call your doctor for instructions if you miss an appointment for your Hycamtin injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include skin rash or other irritation, nausea, vomiting, diarrhea, or mouth sores.

What should I avoid while using Hycamtin?

Avoid driving or hazardous activity until you know how Hycamtin will affect you. Your reactions could be impaired.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What other drugs will affect Hycamtin?

You should not receive a "colony stimulating factor" medicine within 24 hours after your last Hycamtin injection. This includes:

• filgrastim (Neupogen, Granix, Zarxio);

• pegfilgrastim (Neulasta); or

• sargramostim (Leukine).

Other drugs may affect Hycamtin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2025 Cerner Multum, Inc. Version: 9.01.