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Generic name: emapalumab (EM a PAL ue mab)
Brand name: Gamifant
Drug class: Selective immunosuppressants

Medically reviewed by on Jul 20, 2021. Written by Cerner Multum.

What is Gamifant?

Gamifant is used together with a medicine called dexamethasone to treat hemophagocytic lymphohistiocytosis (HLH), a rare disease that is sometimes inherited. HLH causes your immune system to attack healthy blood cells, which can lead to serious or life-threatening side effects on your spleen or liver. This medicine is for use in adults and children as young as newborn.

Gamifant is given after other treatments did not work or have stopped working.

Gamifant may also be used for purposes not listed in this medication guide.


Gamifant affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, night sweats, skin sores, cough, trouble breathing, or cough with bloody mucus.

Before taking this medicine

Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.

Tell your doctor if you have ever had:

  • a positive tuberculosis (TB) skin test;

  • any type of infection (active or recent);

  • histoplasmosis (a fungal infection);

  • herpes zoster (shingles); or

  • if you are scheduled to receive a vaccine.

Tell your doctor if you are pregnant or breastfeeding.

How is Gamifant given?

Before you start treatment with Gamifant, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Gamifant is given as an infusion into a vein, usually once every 3 or 4 days. A healthcare provider will give you this injection.

Gamifant must be given slowly, and the infusion can take about 1 hour to complete.

Gamifant affects your immune system. You may get infections more easily, even serious or fatal infections. You will need blood tests to help your doctor determine how long to treat you with this medicine.

You may be given other medications to help prevent serious infections. Keep using these medicines for as long as your doctor has prescribed.

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What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Gamifant.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Gamifant?

Do not receive a "live" vaccine while using Gamifant and for at least 4 weeks after your last dose. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Gamifant side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel feverish, chilled, sweaty, itchy, light-headed, nauseated, or if you have chest pain, shortness of breath, or skin rash or redness.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

  • fever, chills, night sweats;

  • loss of appetite, weight loss;

  • feeling very tired;

  • warmth, redness, or painful sores on your skin;

  • cough, trouble breathing;

  • mouth and throat ulcers;

  • cough with bloody mucus; or

  • any other new or worsening signs of infection.

Common side effects may include:

  • fever; or

  • increased blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Gamifant?

Other drugs may affect Gamifant, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.